… the ER lead to an evolutionarily conserved cell stress response, the unfolded … cell death if
ER dysfunction is severe or prolonged. The mechanisms by which ER stress leads to cell death …

… Many conditions that impose stress on cells, including hypoxia, starvation, infections and …
capacity of the cell and promote endoplasmic reticulum stress. The cellular response involves …

… and apoptotic cell death. Here, we review evidence for the molecular components involved
in cell death signaling induced by ER stress. Based on their actions in response to ER stress, …

… — cell death is induced, typically by apoptosis. However, ER-stress-induced cell death can
… , and it is clear that the cell death mechanisms triggered as a result of ER stress are diverse, …

… can markedly expand the protein folding capacity of the cell and restore ER homeostasis [6]. …
ER stress is excessive or prolonged, the UPR induces cell death. The cell death pathways …

… However, in metazoans, persistent or intense ER stress can also trigger programmed cell
death, or apoptosis. ER stress and the apoptotic program coupled to it have been implicated in …

… ER also plays a crucial role in the maintenance of cellular calcium homeostasis. Since ER
is a key organelle in the cell; ER stress-mediated cell death can be associated with numerous …

… In order to discern the mechanism(s) by which ER stress triggers cell death pathways, we
developed a cell-free system of ER stress-induced cell death that involves the addition of …

… determine whether ER stress-induced cell death requires the interaction and subsequent
activation of caspases, and if so, which ones. We demonstrate that ER stress not only induces …

… autophagy may help relieve cellular stress and promote cell survival, overactivated
autophagy may lead to cell death (autophagic cell death). In response to ER stress, IRE1 can …