… ER lead to an evolutionarily conserved cell stress response, the unfolded protein … cell death
if ER dysfunction is severe or prolonged. The mechanisms by which ER stress leads to cell …

The proper functioning of the endoplasmic reticulum (ER) is critical for numerous aspects of
cell physiology. Accordingly, all eukaryotes react rapidly to ER dysfunction through a set of …

… cellular responses to endoplasmic reticulum (ER) stress is the activation of the unfolded protein
response (UPR). ER stress … that regulate cell fate following ER stress is limited. The UPR …

In homeostasis, cellular processes are in a dynamic equilibrium. Perturbation of homeostasis
causes stress. In this review I summarize how perturbation of three major functions of the …

… only late in life. Although our understanding of ER stress-induced cell death has advanced
… it remains unclear how these pathways regulate cell death that occurs only decades later. …

… reticulum (ER), a cellular organelle important for the biosynthesis and folding of secretory
proteins such as insulin, in β-cell … environmental factors leading to ER stress. To counteract ER …

… and also independently perturb cellular events that are critically linked to cell life and death.
Perhaps the strongest link between ER calcium regulation and the cell death machinery is …

… cellular, molecular and genetic changes such as oogenesis and spermatogenesis starting
in prenatal life, … and growth factors throughout reproductive life. These reproductive changes …

… protein response (UPR) and endoplasmic reticulum stress signaling (ERSS) in the responses
of oocytes and embryos to environmental stress, the unique consequences that ERSS may …

… Mild ER stress usually triggers adaptation rather than cell death, possibly because mRNA …
preferentially targets proapoptotic proteins with a shorter half-life [69]. Many studies have also …