Role of endoplasmic reticulum stress in hepatic glucose and lipid metabolism and therapeutic strategies for metabolic liver disease
W Zheng, Q Sun, L Li, Y Cheng, Y Chen, M Lv… - International …, 2022 - Elsevier
… In summary, under endoplasmic reticulum stress induced by various nutritional statuses,
activation of the IRE1α pathway has different metabolic effects on hepatic glucose metabolism, …
activation of the IRE1α pathway has different metabolic effects on hepatic glucose metabolism, …
Infusion of glucose and lipids at physiological rates causes acute endoplasmic reticulum stress in rat liver
G Boden, W Song, X Duan, P Cheung, K Kresge… - …, 2011 - Wiley Online Library
… a marginally higher degree of hepatic ER stress than the glycerol/glucose/ insulin infusions,
… caused hepatic insulin resistance as evidenced by inhibition of insulin stimulation of glucose …
… caused hepatic insulin resistance as evidenced by inhibition of insulin stimulation of glucose …
Endoplasmic reticulum stress increases glucose-6-phosphatase and glucose cycling in liver cells
D Wang, Y Wei, D Schmoll, KN Maclean… - …, 2006 - academic.oup.com
… Impaired regulation of hepatic glucose production is a … It has been proposed that sustained
endoplasmic reticulum stress, … reticulum stress increases expression and activity of glucose-…
endoplasmic reticulum stress, … reticulum stress increases expression and activity of glucose-…
Glucose-induced beta cell dysfunction in vivo in rats: link between oxidative stress and endoplasmic reticulum stress
C Tang, K Koulajian, I Schuiki, L Zhang, T Desai… - Diabetologia, 2012 - Springer
… Insulin clearance is mainly a liver function, and is generally proportional to hepatic insulin
sensitivity. Thus, PBA may prevent glucose-induced hepatic insulin resistance. As PBA can …
sensitivity. Thus, PBA may prevent glucose-induced hepatic insulin resistance. As PBA can …
Resveratrol reduces liver endoplasmic reticulum stress and improves insulin sensitivity in vivo and in vitro
H Zhao, Y Zhang, L Shu, G Song… - Drug design, development …, 2019 - Taylor & Francis
… The liver is an insulin-sensitive organ, and hepatic disorders of glucose and lipid … and
glucose transport, thereby enhancing the glucose pathway and lowering blood glucose levels. …
glucose transport, thereby enhancing the glucose pathway and lowering blood glucose levels. …
β-aminoisobutyric acid attenuates hepatic endoplasmic reticulum stress and glucose/lipid metabolic disturbance in mice with type 2 diabetes
… BAIBA on hepatic endoplasmic reticulum (ER) stress and glucose/… glucose and lipids levels,
hepatic key enzymes of gluconeogenesis and lipogenesis expressions, attenuated hepatic …
hepatic key enzymes of gluconeogenesis and lipogenesis expressions, attenuated hepatic …
Endoplasmic reticulum stress inducer tunicamycin alters hepatic energy homeostasis in mice
B Feng, X Huang, D Jiang, L Hua, Y Zhuo… - International journal of …, 2017 - mdpi.com
… In the current study, the effects of 24 h tunicamycin treatment on serum lipids profiles, hepatic
triglyceride accumulation, blood glucose level and liver glycogen content were explored …
triglyceride accumulation, blood glucose level and liver glycogen content were explored …
Astragalus polysaccharide reduces hepatic endoplasmic reticulum stress and restores glucose homeostasis in a diabetic KKAy mouse model1
… hepatic glucose metabolism and insulin action, we observed the expression and activity of
hepatic … normalization of blood glucose levels and improved hepatic and peripheral insulin …
hepatic … normalization of blood glucose levels and improved hepatic and peripheral insulin …
Endoplasmic reticulum stress, obesity and diabetes
M Cnop, F Foufelle, LA Velloso - Trends in molecular medicine, 2012 - cell.com
… Hepatic ER stress contributes to the development of steatosis and insulin resistance, and …
Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress. …
Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress. …
Endoplasmic reticulum stress as the basis of obesity and metabolic diseases: focus on adipose tissue, liver, and pancreas
A Fernandes-da-Silva, CS Miranda… - European journal of …, 2021 - Springer
… ER stress, compromising browning and thermogenesis, favoring hepatic lipogenesis, and
impairing glucose-… As a result, ER stress takes part in obesity, hepatic steatosis, and diabetes …
impairing glucose-… As a result, ER stress takes part in obesity, hepatic steatosis, and diabetes …
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