Endoplasmic reticulum stress and lipid metabolism: mechanisms and therapeutic potential

S Basseri, RC Austin - Biochemistry research international, 2012 - Wiley Online Library
stress/UPR activation plays a critical role in lipid metabolism … ER-stress-dependent
dysregulation of lipid metabolism may … ER stress/UPR signalling pathways play in regulation of …

The role of ER stress in lipid metabolism and lipotoxicity

J Han, RJ Kaufman - Journal of lipid research, 2016 - ASBMB
reticulum (ER) is a cellular organelle important for regulating calcium homeostasis, lipid
metabolism, … protein and activated by proteolysis in response to endoplasmic reticulum stress. …

[HTML][HTML] Lipophagy mediated carbohydrate-induced changes of lipid metabolism via oxidative stress, endoplasmic reticulum (ER) stress and ChREBP/PPARγ …

T Zhao, K Wu, C Hogstrand, YH Xu, GH Chen… - Cellular and Molecular …, 2020 - Springer
… and HG-induced changes of lipid metabolism were via enhancing … changes of lipid metabolism
by oxidative stress and ER stress, … and lipid metabolism via ChREBP/PPARγ pathway. …

The role of endoplasmic reticulum in hepatic lipid homeostasis and stress signaling

S Fu, SM Watkins, GS Hotamisligil - Cell metabolism, 2012 - cell.com
Lipid metabolism occurs primarily at the ER, where many of the enzymes involved in
intermediary and complex lipid metabolism reside, giving the ER a central but under-investigated …

[HTML][HTML] A guide to understanding endoplasmic reticulum stress in metabolic disorders

IL Lemmer, N Willemsen, N Hilal, A Bartelt - Molecular metabolism, 2021 - Elsevier
… Therefore, disturbances in proteostasis, for example, will impact lipid metabolism in the
ER and vice versa. This is especially true in obesity, where continuous metabolic pressure …

[HTML][HTML] Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity

S Fu, L Yang, P Li, O Hofmann, L Dicker, W Hide, X Lin… - Nature, 2011 - nature.com
… defects, reduce ER stress and improve metabolism, supporting the hypothesis that changes
in lipid metabolism contribute to SERCA dysfunction, ER stress and hyperglycaemia in both …

Role of endoplasmic reticulum stress in hepatic glucose and lipid metabolism and therapeutic strategies for metabolic liver disease

W Zheng, Q Sun, L Li, Y Cheng, Y Chen, M Lv… - International …, 2022 - Elsevier
… Endoplasmic reticulum stress plays a very important role in … and lipid metabolism and
discusses the mechanism linking endoplasmic reticulum stress with glucose and lipid metabolism

[HTML][HTML] Endoplasmic reticulum stress affects lipid metabolism in atherosclerosis via CHOP activation and over-expression of miR-33

Y Sun, D Zhang, X Liu, X Li, F Liu, Y Yu, S Jia… - Cellular Physiology and …, 2018 - karger.com
reticulum (ER) stress is an important event in atherosclerosis. Recent studies have shown
that ER stress deregulates cholesterol metabolism via … ER stress and lipid metabolism and to …

Mitochondrial dysfunction, through impaired autophagy, leads to endoplasmic reticulum stress, deregulated lipid metabolism, and pancreatitis in animal models

G Biczo, ET Vegh, N Shalbueva, OA Mareninova… - Gastroenterology, 2018 - Elsevier
… We find deregulation of acinar cell lipid metabolism in AP. The impaired autophagy, ER
stress, and deregulated lipid metabolism are all mediated by mitochondrial dysfunction and …

Endoplasmic reticulum stress and lipid dysregulation

SM Colgan, AA Al-Hashimi, RC Austin - Expert reviews in molecular …, 2011 - cambridge.org
… These findings suggest that caspase-3 or other caspases might function independently of
apoptotic cell death and have a role in cellular lipid metabolism. Although ER …