Clozapine worsens glucose intolerance, nonalcoholic fatty liver disease, kidney damage, and retinal injury and increases renal reactive oxygen species production …

GR Chang, HY Liu, WC Yang, CM Wang… - International Journal of …, 2021 - mdpi.com
… insulin sensitivity, greater glucose intolerance, and less Akt … Moreover, clozapine reduced
the thickness of retinal cell … , diabetes, and kidney and retinal injury. Therefore, long-term …

[HTML][HTML] Impact of obesity with impaired glucose tolerance on retinal degeneration in a rat model of metabolic syndrome

KK Godisela, SS Reddy, CU Kumar, N Saravanan… - Molecular …, 2017 - ncbi.nlm.nih.gov
glucose intolerance developed retinal degeneration similar to the parent line WNIN/Ob. The
severity of retinal … of MetS, glucose intolerance (IGT), and obesity on retinal degeneration. …

Microvascular complications of impaired glucose tolerance

JR Singleton, AG Smith, JW Russell, EL Feldman - Diabetes, 2003 - Am Diabetes Assoc
retinal injury occurs during IGT. Indeed, metaanalysis suggests that risk for retinopathy or
nephropathy begins to increase with a 2-h glucose … history of progressive glucose intolerance; …

Early impairments in the retina of rats fed with high fructose/high fat diet are associated with glucose metabolism deregulation but not dyslipidaemia

E Vidal, E Lalarme, MA Maire, V Febvret, S Grégoire… - Scientific reports, 2019 - nature.com
… Our results showed that HFHF diet induced fasted hyperglycaemia, glucose intolerance, …
, as soon as there is a retinal injury. Sustained injury induced by impact laser in the Bruch’s …

Diabetic retinopathy: seeing beyond glucose-induced microvascular disease

DA Antonetti, AJ Barber, SK Bronson, WM Freeman… - Diabetes, 2006 - Am Diabetes Assoc
… outer retina fully oxidize glucose to CO 2 and water via oxidative phosphorylation (24). In the
inner retina, metabolic substrates, such as glucose, … mechanisms of retinal injury and stress …

Glucose tolerance and insulin resistance/sensitivity associate with retinal layer characteristics: the LIFE-Adult-Study

FG Rauscher, T Elze, M Francke, ME Martinez-Perez… - Diabetologia, 2024 - Springer
… of the retina showed significant sex- and glucose … of glucose intolerance and insulin resistance
(eg HOMA2-IR) with the thickness of the optical bands representing the anatomical retinal

Early retinal damage in experimental diabetes: electroretinographical and morphological observations

Q Li, E Zemel, B Miller, I Perlman - Experimental eye research, 2002 - Elsevier
glucose and body weight conducted in most rats control and diabetes) before ERG testing or
before they were killed and their retinas … the old and glucose-intolerant genetically obese fa/…

Functional deficits precede structural lesions in mice with high-fat diet–induced diabetic retinopathy

R Rajagopal, GW Bligard, S Zhang, L Yin… - Diabetes, 2016 - Am Diabetes Assoc
… abnormalities were correlated with glucose intolerance. Unexpectedly, retinas from high
fat–fed … vascular injury. This functional abnormality persists to 12 months and is correlated with …

Association between prediabetes/hyperglycemia and retinal diseases: A meta-analysis

T Wang, L Kuang, X Yao, R Gan… - European Journal of …, 2023 - journals.sagepub.com
… “impaired fasting glucose” or “impaired glucose intolerance” or “… between blood glucose and
development of retinal diseases … alterations prior to microvascular injury in prediabetes. The …

High incidence of glucose intolerance in Vogt–Koyanagi–Harada disease

N Yawata, S Nakamura, M Kijima, N Ikai… - British journal of …, 1999 - bjo.bmj.com
… All patients had acute bilateral panuveitis with serous retinal … that the mode of glucose
intolerance may be by way of … Cytotoxic T cells have been considered as a key agent in injury of …