Pharmacological activity of retinoic acid receptor alpha-selective antagonists in vitro and in vivo
SSW Chung, RAD Cuellar, X Wang… - ACS medicinal …, 2013 - ACS Publications
… of a retinoic acid receptor (RAR) pan-antagonist reversibly … we identified two RARα-selective
antagonists by transactivation and … Although these two antagonists were potent in vitro, they …
antagonists by transactivation and … Although these two antagonists were potent in vitro, they …
Different agonist-and antagonist-induced conformational changes in retinoic acid receptors analyzed by protease mapping
S Keidel, P LeMotte, C Apfel - Molecular and Cellular Biology, 1994 - Taylor & Francis
… [35S]methionine-labeled RARa translated in vitro was incubated with retinoids or DMSO
alone and then digested with several concentrations of trypsin or other proteases. The digestion …
alone and then digested with several concentrations of trypsin or other proteases. The digestion …
Retinoic acid regulates arterial smooth muscle cell proliferation and phenotypic features in vivo and in vitro through an RARα-dependent signaling pathway
P Neuville, ZQ Yan, A Gidlof, MS Pepper… - … , and vascular biology, 1999 - Am Heart Assoc
… retinoic acid (tRA) modulates arterial smooth muscle cell (SMC) morphologic features and
biochemical composition in vitro. It … Our results show that tRA and synthetic retinoids can affect …
biochemical composition in vitro. It … Our results show that tRA and synthetic retinoids can affect …
In vitro antimalarial activity of retinoids and the influence of selective retinoic acid receptor antagonists
… The cellular differentiating and anti-proliferating effects of retinoids are believed to be
induced by retinoic acid receptor (RAR) and retinoid X receptor (RXR) heterodimer interactions (…
induced by retinoic acid receptor (RAR) and retinoid X receptor (RXR) heterodimer interactions (…
All-trans Retinoic Acid Induces in Vitro Angiogenesis via Retinoic Acid Receptor: Possible Involvement of Paracrine Effects of Endogenous Vascular Endothelial …
A Saito, A Sugawara, A Uruno, M Kudo… - …, 2007 - academic.oup.com
… retinoid all-trans retinoic acid (ATRA) regulates a variety of important cellular functions via
retinoic acid … We therefore examined ATRA effects on in vitro angiogenesis in terms of capillary…
retinoic acid … We therefore examined ATRA effects on in vitro angiogenesis in terms of capillary…
A retinoic acid receptor α antagonist counteracts retinoid teratogenicity in vitro and reduced incidence and/or severity of malformations in vivo
K Eckhardt, G Schmitt - Toxicology letters, 1994 - Elsevier
… The role of retinoic acid receptors (RAR) in retinoid-… antagonist on retinoid-induced
teratogenic effects in vitro and in vivo. In micromass cultures of rat limb bud cells a RARa antagonist …
teratogenic effects in vitro and in vivo. In micromass cultures of rat limb bud cells a RARa antagonist …
Retinoic acid signaling biomarkers after treatment with retinoic acid and retinoic acid receptor alpha antagonist (Ro 41-5253) in canine testis: an in vitro organ culture …
VR Kasimanickam, RK Kasimanickam - Theriogenology, 2013 - Elsevier
… retinoic acid (RA) or RARα antagonist (Ro 41-5253) in a canine organ culture model (N =
5). Within RA or RARα antagonist … ALDH1, aldehyde dehydrogenase 1; RARα, retinoic acid …
5). Within RA or RARα antagonist … ALDH1, aldehyde dehydrogenase 1; RARα, retinoic acid …
[HTML][HTML] Control of retinoic acid receptor heterodimerization by ligand-induced structural transitions: A novel mechanism of action for retinoid antagonists
C Depoix, MH Delmotte, P Formstecher… - Journal of Biological …, 2001 - ASBMB
… to DNA and for retinoic acid-induced gene regulation. Whether retinoids control RXR/RAR
solution interaction remains a debated question, and we have usedin vitro and in vivo protein …
solution interaction remains a debated question, and we have usedin vitro and in vivo protein …
9-cis-retinoic acid is a natural antagonist for the retinoic acid receptor response pathway
C Carlberg, JH Saurat, G Siegenthaler - Biochemical Journal, 1993 - portlandpress.com
… retinoids are mediated by two types of nuclear receptors, the retinoic acid receptors (RARs)
and the retinoid X … RAR homodimer complexes were destabilized in vitro in the presence of 9-…
and the retinoid X … RAR homodimer complexes were destabilized in vitro in the presence of 9-…
[HTML][HTML] Effects of novel retinoid X receptor-selective ligands on myeloid leukemic differentiation and proliferation in vitro
M Kizaki, MI Dawson, R Heyman, E Elstner, R Morosetti… - Blood, 1996 - Elsevier
… The biologic effects of retinoids such as all-trans-retinoic acid (ATRA) and 9-cis-retinoic acid
… of transcription factors: the retinoic acid receptors (RARs) and the retinoid X receptors (RXRs…
… of transcription factors: the retinoic acid receptors (RARs) and the retinoid X receptors (RXRs…
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