… Using designer receptors exclusively activated by designer drugs (… and reversible regulation
of neuronal activity in mice, we have demonstrated that acute activation of AgRP neurons …

… chemo- and optogenetic activation of AgRP neurons induces insulin resistance … AgRP
neuron activation does not occur in NPY genetic knockout mice. Since this observation is reversed …

… if the recorded AgRP neuron synapsed onto the recorded POMC neuron, we injected a … 4
min) into the AgRP neuron and monitored the firing activity of POMC neurons under the current-…

… AgRP neurons, which also co-produce neuropeptide Y (NPY) and γ-Aminobutyric acid (…
models targeting AgRP neurons and the tools used to discern the role of this specific neuronal …

… Stimulation of AgRP neurons rapidly and reversibly increased cumulative food intake (left)
and mean feeding rate (right) following administration of saline (A, B), amylin (C, D), CCK (E, F…

… , reversible activation of AgRP neurons … AgRP stimulation, we acutely activated AgRP
neurons in mice that could not either release GABA (AgRP-ires-Cre; Vgat flox/flox ) or NPY (AgRP-…

… , AgRP but not POMC neurons have dendritic spines and increased glutamatergic input onto
AgRP neurons … play key roles in controlling AgRP neurons and determining the cellular and …

… To gain insight into the physiological regulation of AgRP neurons, we monitored AgRP
neuron calcium dynamics in freely moving animals. Fiber photometry was performed in animals …

… Using models of neuronal inhibition or ablation, we demonstrate that the feeding response
… relies on AgRP neurons. However, when palatable food is provided, AgRP neurons are …

… obesity reversibly blunts the rapid inhibition of AgRP neurons … AgRP neuron activation, our
findings also suggest that downstream circuits may have reduced sensitivity to AgRP neuron …