… review was to establish the frequency with which trials take into account missingness, and to
discover what methods trialists use for adjustment in randomised controlled trials … trials with …

… can be refined in the statistical analysis plan during the blind review of the data. This is a very
… results of the analysis to the method of handling missing data, that is, sensitivity analysis. …

… In this article, we review the mechanisms of missing data and some common approaches to
… utilized statistical methods for the analysis of clinical trial data with dropouts. The methods …

… above two documents, provide a more detailed review of the basic concepts of missing data
… one clinical program at protocol design, data analysis plan and other stages of a clinical trial…

… The review of this report was overseen by Gilbert S. Omenn, … Appointed by the NRC’s
Report Review Committee, they … procedures and that all review comments were carefully …

… Before the assessments, we independently underwent three rounds of calibration by evaluating
6 RCTs not included in the present review. We selected these RCTs by using an online …

… trials almost always have some individuals with missing outcomes. Inadequate handling of
… We examine how missing outcome data are handled in randomized controlled trials in order …

… that different approaches to handling missing data can lead … clinical trials of carrying the
last observation forward to impute missing values should not be the primary analysis. We review …

… We review all these procedures, present a few new simulation studies, and conclude with …
of the clinical trial is of great importance. While the implementation of the clinical trial can often …

… The review of this report was overseen by Joseph T. Coyle, MD, Chair, Consolidated …
accordance with institutional procedures and that all review comments were carefully considered. …