Immune complexes from rheumatoid arthritis synovial fluid induce FcγRIIa dependent and rheumatoid factor correlated production of tumour necrosis factor-α by …

L Mathsson, J Lampa, M Mullazehi… - Arthritis research & …, 2006 - Springer
… We also report that IC-induced TNF-α production is partly mediated via FcγRIIa with
monocytes/macrophages as the main or perhaps only responder cells. These findings support the …

Pro-and anti-inflammatory cytokines in rheumatoid arthritis

P Isomäki, J Punnonen - Annals of medicine, 1997 - Taylor & Francis
… Granulocyte/macrophage colony-stimulating factor-mediated … on human monocytes: possible
role in rheumatoid arthritis. J Exp … fluid macrophages from patients with rheumatoid arthritis. …

Synovial biology and T cells in rheumatoid arthritis

CN Tran, SK Lundy, DA Fox - Pathophysiology, 2005 - Elsevier
… T cells also interact with monocytes and macrophages and … cytokine TNFα by synovial
macrophages. Recent evidence … Rheumatoid arthritis synovium may be one of the most striking …

Cell signalling in macrophages, the principal innate immune effector cells of rheumatoid arthritis

SK Drexler, PL Kong, J Wales, BM Foxwell - Arthritis research & therapy, 2008 - Springer
… innate immune cells in rheumatoid arthritis progression. Therefore, … in innate immune cells
in the context of rheumatoid arthritis. … on macrophages/monocytes during rheumatoid arthritis

Blood monocyte activation in rheumatoid arthritis: increased monocyte adhesiveness, integrin expression, and cytokine release

F Liote, B Boval-Boizard, D Weill… - Clinical & …, 1996 - academic.oup.com
… adhesion to endothelium is a crucial step in the migration process that precedes monocyte
differentiation to tissue macrophages and type A synoviocytes [6]. Several ligands that are …

The immunology of rheumatoid arthritis

CM Weyand, JJ Goronzy - Nature immunology, 2021 - nature.com
… -derived monocytes rapidly travel to injured tissues sites and join the resident macrophage
… In labeling studies, the pool of synovial macrophages was predominantly dependent on the …

Rheumatoid arthritis CD14+ monocytes display metabolic and inflammatory dysfunction, a phenotype that precedes clinical manifestation of disease

T McGarry, MM Hanlon, V Marzaioli… - Clinical & …, 2021 - Wiley Online Library
… During inflammation, monocytes have been shown to preferentially differentiate into
inflammatory macrophages in response to local macrophage colony-stimulating factor (M-CSF), a …

Synovial stromal cells from rheumatoid arthritis patients attract monocytes by producing MCP-1 and IL-8

K Hayashida, T Nanki, H Girschick, S Yavuz… - Arthritis Research & …, 2001 - Springer
Macrophages that accumulate in the synovium of … The results of this study show that
rheumatoid arthritis synovial stromal cells produce the chemokines monocyte chemotactic protein-1 …

Cellular and molecular perspectives in rheumatoid arthritis

DJ Veale, C Orr, U Fearon - Seminars in Immunopathology, 2017 - Springer
… Synovial immunopathology in rheumatoid arthritis is complex involving both … monocyte-derived
phagocytes that specialise in the removal of pathogens and cellular debris. Macrophages

… monocyte/macrophage activation and differentiation antigens and identify functionally distinct subpopulations of human rheumatoid synovial tissue macrophages.

AE Koch, JC Burrows, A Skoutelis… - The American journal …, 1991 - ncbi.nlm.nih.gov
… Radioimmunoassays wereperformed simultaneously on blood monocytes and
rheumatoid arthritis tissue macrophages. The results represent the mean of determination on …