… synovium compared with osteoarthritis tissue. In contrast, TIMP gene expression was similar
… types of arthritis. The balance in rheumatoid arthritis appears to favor tissue destruction, …

The transcription factor NF-κB has been well recognized as a pivotal regulator of inflammation
in rheumatoid arthritis (RA), but recent developments revealed a broad involvement of NF-…

… destruction of the extracellular matrices of these tissues [2]. Furthermore, the validation of a
major role for these cytokines in joint destruction … inhibition of tissue destruction. This review …

… Rheumatoid arthritis is an autoimmune disease characterized by the production of two known
antibodies – rheumatoid … Tissue destruction is not only the result of chronic inflammation …

… for the pathogenesis of rheumatoid joint destruction. First, … and bone as a granulation
tissue called “pannus” but also … cross-talk that is crucial to arthritic joint destruction, and thus, …

… from patients with clinically evident adult rheumatoid arthritis and formed the subject matter of
… cases of rheumatoid arthritis in which we were able to see articular cartilage destruction 70 …

… Rheumatoid arthritis is a complex systemic disease that ultimately leads to the progressive
destruction … The deleterious process of joint destruction is mediated by intracellular signaling …

The immunological disturbance in rheumatoid arthritis (RA) gives rise to a nonspecific
inflammatory reaction mediated by cells and cytokines. This immunological nonbacterial synovitis, …

… Blockade of synovitis, however, remains the ultimate goal for reducing the inflammatory
aspects of RA as well as preventing tissue destruction. The advent of biologic therapy targeting IL…

… 8 Excessive tumor-like proliferation in the synovial tissue in rheumatoid arthritis. Large, in …
in destruction. A condition for the destruction of cartilage and bone in rheumatoid arthritis is the …