… of the known OA risk factors and relevant mechanisms of action. In addition, given that the
lack of biologically relevant models to recapitulate human OA pathogenesis represents one of …

Osteoarthritis (OA) represents a large burden on healthcare resources worldwide with
continually increasing prevalence. This has led to renewed interest in the causes and …

… Because osteoarthritis consists of end-stage joint damage, I propose that risk factors for …
protectors, increasing joint vulnerability, or as factors that excessively load the joint, leading to …

… Other risk factors include sex, race and ethnicity, genetics, nutrition, smoking, and injuries/…
or more of the other risk factors. The relative significance of certain risk factors may differ from …

… of OA and identify features common to the primary risk factors for OA (aging, obesity and joint
trauma… This analysis supports a unified view of the pathogenesis of OA such that the risk for …

The prevalence of osteoarthritis (OA) is rising for reasons that are not fully understood. In
this Opinion article, we review the possibility that OA is an evolutionary mismatch disease, …

… OA osteoarthritis This review addresses the epidemiology of metabolic milieu risk factors
that are systemically associated with osteoarthritis (OA) , rather than local risk factors. Though …

… in particular squatting and kneeling are common risk factors of knee OA. Several … to
prevalence, pathogenesis, risk factors. Key Words: Knee, Osteoarthritis, Pathogenesis, Prevalence …

… With OA having several risk factors and various causes and contributing elements, it is
important to elucidate the pathogenesis of OA and determine exactly how risk factors play a role …

… demonstrated that osteoarthritis is a complex trait with numerous environmental and genetic
risk factors. A great deal of effort has been spent elucidating these risk factors and progress …