[HTML][HTML] Genome-wide study of atrial fibrillation identifies seven risk loci and highlights biological pathways and regulatory elements involved in cardiac development
… and a major risk factor for stroke, heart failure, and premature death. The pathogenesis of …
genome and identified seven risk loci, including two novel loci. One novel locus (lead single-…
genome and identified seven risk loci, including two novel loci. One novel locus (lead single-…
[HTML][HTML] Identification of 15 novel risk loci for coronary artery disease and genetic risk of recurrent events, atrial fibrillation and heart failure
N Verweij, RN Eppinga, Y Hagemeijer… - Scientific reports, 2017 - nature.com
… heart failure and atrial fibrillation. In conclusion, we substantially increased the number of
loci convincingly associated with CAD and provide additional biological and clinical insights. …
loci convincingly associated with CAD and provide additional biological and clinical insights. …
[HTML][HTML] Atrial fibrillation risk loci interact to modulate Ca2+-dependent atrial rhythm homeostasis
B Laforest, W Dai, L Tyan, S Lazarevic… - The Journal of …, 2019 - Am Soc Clin Investig
… for understanding the combined impact of genetic variants across genomes for disease risk
… genetic risk loci will be an essential component of understanding personalized risk from …
… genetic risk loci will be an essential component of understanding personalized risk from …
[HTML][HTML] Long-range regulatory interactions at the 4q25 atrial fibrillation risk locus involve PITX2c and ENPEP
LA Aguirre, ME Alonso, C Badía-Careaga, I Rollán… - BMC biology, 2015 - Springer
… association studies have uncovered genomic loci that underlie an increased risk for atrial
fibrillation, the major cardiac arrhythmia in humans. The most significant locus is located in a …
fibrillation, the major cardiac arrhythmia in humans. The most significant locus is located in a …
New advances in the genetic basis of atrial fibrillation
S Mahida, PT Ellinor - Journal of cardiovascular …, 2012 - Wiley Online Library
… risk loci that confer increased susceptibility to the arrhythmia. … field as 9 risk loci have been
identified for the arrhythmia, 12–15 … Firstly, the causal variants at the AF risk loci have not been …
identified for the arrhythmia, 12–15 … Firstly, the causal variants at the AF risk loci have not been …
Emerging directions in the genetics of atrial fibrillation
NR Tucker, PT Ellinor - Circulation research, 2014 - Am Heart Assoc
… A logical extension of this work would then be to determine if these subthreshold loci are
additional potential AF genetic risk loci. Genotyping AF-associated SNPs from these …
additional potential AF genetic risk loci. Genotyping AF-associated SNPs from these …
Atrial fibrillation genetics: is there a practical clinical value now or in the future?
WJ Hucker, H Saini, SA Lubitz, PT Ellinor - Canadian Journal of Cardiology, 2016 - Elsevier
… As noted, the AF risk locus at PITX2/4q25 is by far the most well studied of the risk loci
identified to date. Because approximately 20% of individuals of European ancestry carry at least …
identified to date. Because approximately 20% of individuals of European ancestry carry at least …
Common atrial fibrillation risk alleles at 4q25 predict recurrence after catheter-based atrial fibrillation ablation
MB Shoemaker, R Muhammad, B Parvez, BW White… - Heart rhythm, 2013 - Elsevier
… Our study sought to examine the 4q25 AF risk locus identified by genome-wide association
studies.8, 9, 10 The minor allele frequency for the SNPs examined ranges from 13% (…
studies.8, 9, 10 The minor allele frequency for the SNPs examined ranges from 13% (…
Meta-analysis identifies six new susceptibility loci for atrial fibrillation
PT Ellinor, KL Lunetta, CM Albert, NL Glazer… - Nature …, 2012 - nature.com
… We identified ten loci that exceeded our preset threshold for genome… loci most significantly
associated with atrial fibrillation were at previously identified atrial fibrillation susceptibility loci …
associated with atrial fibrillation were at previously identified atrial fibrillation susceptibility loci …
Genetic risk prediction of atrial fibrillation
SA Lubitz, X Yin, HJ Lin, M Kolek, JG Smith… - Circulation, 2017 - Am Heart Assoc
… can stratify risk for development of AF, we examined associations between AF genetic risk
scores … We examined associations between AF genetic risk scores and ischemic stroke in a …
scores … We examined associations between AF genetic risk scores and ischemic stroke in a …
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