… and a major risk factor for stroke, heart failure, and premature death. The pathogenesis of …
genome and identified seven risk loci, including two novel loci. One novel locus (lead single-…

… heart failure and atrial fibrillation. In conclusion, we substantially increased the number of
loci convincingly associated with CAD and provide additional biological and clinical insights. …

… for understanding the combined impact of genetic variants across genomes for disease risk
… genetic risk loci will be an essential component of understanding personalized risk from …

… association studies have uncovered genomic loci that underlie an increased risk for atrial
fibrillation, the major cardiac arrhythmia in humans. The most significant locus is located in a …

… risk loci that confer increased susceptibility to the arrhythmia. … field as 9 risk loci have been
identified for the arrhythmia, 12–15 … Firstly, the causal variants at the AF risk loci have not been …

… A logical extension of this work would then be to determine if these subthreshold loci are
additional potential AF genetic risk loci. Genotyping AF-associated SNPs from these …

… As noted, the AF risk locus at PITX2/4q25 is by far the most well studied of the risk loci
identified to date. Because approximately 20% of individuals of European ancestry carry at least …

… Our study sought to examine the 4q25 AF risk locus identified by genome-wide association
studies.8, 9, 10 The minor allele frequency for the SNPs examined ranges from 13% (…

… We identified ten loci that exceeded our preset threshold for genome… loci most significantly
associated with atrial fibrillation were at previously identified atrial fibrillation susceptibility loci …

… can stratify risk for development of AF, we examined associations between AF genetic risk
scores … We examined associations between AF genetic risk scores and ischemic stroke in a …