A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry
… A diagnosis of COPD is based on post bronchodilator spirometric measures … measure of
airflow obstruction [3]. Understanding the genetics underlying these spirometric measurements …
airflow obstruction [3]. Understanding the genetics underlying these spirometric measurements …
Genetic loci influencing lung function: a genomewide scan in the Framingham study
O Joost, JB Wilk, L Adrienne Cupples… - American journal of …, 2002 - atsjournals.org
… , and smoking status on spirometric measures were adjusted through … The residual spirometric
measures were analyzed for linkage to … The loci most strongly influencing FEV 1 and FVC …
measures were analyzed for linkage to … The loci most strongly influencing FEV 1 and FVC …
The association of genome-wide significant spirometric loci with chronic obstructive pulmonary disease susceptibility
PJ Castaldi, MH Cho, AA Litonjua, P Bakke… - American journal of …, 2011 - atsjournals.org
… locus including AGER and PPT2, and the 5q33 locus including ADAM19. In conclusion, markers
previously associated at or near GWS with spirometric measures … and three loci showed …
previously associated at or near GWS with spirometric measures … and three loci showed …
Genetic risk factors for the development of pulmonary disease identified by genome‐wide association
… of spirometric measurements and the heritability of lung function measures have been …
non-asthmatic controls and identified 27 loci contributing to the risk to develop asthma.54 This …
non-asthmatic controls and identified 27 loci contributing to the risk to develop asthma.54 This …
A genetic risk score associated with chronic obstructive pulmonary disease susceptibility and lung structure on computed tomography
EC Oelsner, VE Ortega, BM Smith… - American journal of …, 2019 - atsjournals.org
… MESA Lung (23) comprised a random subsample with baseline endothelial function
measurement, genetic consent, and spirometry in 2004–2006; participants in MESA Air, which …
measurement, genetic consent, and spirometry in 2004–2006; participants in MESA Air, which …
Effect of five genetic variants associated with lung function on the risk of chronic obstructive lung disease, and their joint effects on lung function
M Soler Artigas, LV Wain, E Repapi… - American journal of …, 2011 - atsjournals.org
… of the risk alleles at all five novel loci described previously (… measure postbronchodilation
spirometry, and therefore our analysis was limited to prebronchodilation spirometry measures. …
spirometry, and therefore our analysis was limited to prebronchodilation spirometry measures. …
Inference of chronic obstructive pulmonary disease with deep learning on raw spirograms identifies new genetic loci and improves risk models
… to provide a COPD risk score that has increased power to detect genetic associations and
stronger associations with outcomes than standard spirometry measures. Our previous work …
stronger associations with outcomes than standard spirometry measures. Our previous work …
Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function
… Spirometric measures of lung function are heritable traits that reflect respiratory health and
… for two clinically important lung-function measures: forced expiratory volume in the first …
… for two clinically important lung-function measures: forced expiratory volume in the first …
Genome-wide association study of preserved ratio impaired spirometry (PRISm)
DH Higbee, A Lirio, F Hamilton… - European …, 2024 - Eur Respiratory Soc
… PRISm is a diagnosis based on spirometry, as opposed to a … based on spirometric criteria
has discovered loci that have … , as well as how spirometric measures are routinely used for …
has discovered loci that have … , as well as how spirometric measures are routinely used for …
Genome-wide linkage analysis of bronchodilator responsiveness and post-bronchodilator spirometric phenotypes in chronic obstructive pulmonary disease
LJ Palmer, JC Celedón, HA Chapman… - Human molecular …, 2003 - academic.oup.com
… loci on chromosomes 2q and 8p, and further suggest that post-bronchodilator spirometric
measures are … This study has also identified several genomic regions that could contain loci …
measures are … This study has also identified several genomic regions that could contain loci …