A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry

SM Lutz, MH Cho, K Young, CP Hersh, PJ Castaldi… - BMC genetics, 2015 - Springer
… A diagnosis of COPD is based on post bronchodilator spirometric measuresmeasure of
airflow obstruction [3]. Understanding the genetics underlying these spirometric measurements

Genetic loci influencing lung function: a genomewide scan in the Framingham study

O Joost, JB Wilk, L Adrienne Cupples… - American journal of …, 2002 - atsjournals.org
… , and smoking status on spirometric measures were adjusted through … The residual spirometric
measures were analyzed for linkage to … The loci most strongly influencing FEV 1 and FVC …

The association of genome-wide significant spirometric loci with chronic obstructive pulmonary disease susceptibility

PJ Castaldi, MH Cho, AA Litonjua, P Bakke… - American journal of …, 2011 - atsjournals.org
locus including AGER and PPT2, and the 5q33 locus including ADAM19. In conclusion, markers
previously associated at or near GWS with spirometric measures … and three loci showed …

Genetic risk factors for the development of pulmonary disease identified by genome‐wide association

R Hall, IP Hall, I Sayers - Respirology, 2019 - Wiley Online Library
… of spirometric measurements and the heritability of lung function measures have been …
non-asthmatic controls and identified 27 loci contributing to the risk to develop asthma.54 This …

A genetic risk score associated with chronic obstructive pulmonary disease susceptibility and lung structure on computed tomography

EC Oelsner, VE Ortega, BM Smith… - American journal of …, 2019 - atsjournals.org
… MESA Lung (23) comprised a random subsample with baseline endothelial function
measurement, genetic consent, and spirometry in 2004–2006; participants in MESA Air, which …

Effect of five genetic variants associated with lung function on the risk of chronic obstructive lung disease, and their joint effects on lung function

M Soler Artigas, LV Wain, E Repapi… - American journal of …, 2011 - atsjournals.org
… of the risk alleles at all five novel loci described previously (… measure postbronchodilation
spirometry, and therefore our analysis was limited to prebronchodilation spirometry measures. …

Inference of chronic obstructive pulmonary disease with deep learning on raw spirograms identifies new genetic loci and improves risk models

J Cosentino, B Behsaz, B Alipanahi, ZR McCaw… - Nature Genetics, 2023 - nature.com
… to provide a COPD risk score that has increased power to detect genetic associations and
stronger associations with outcomes than standard spirometry measures. Our previous work …

Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function

DB Hancock, M Eijgelsheim, JB Wilk, SA Gharib… - Nature …, 2010 - nature.com
Spirometric measures of lung function are heritable traits that reflect respiratory health and
… for two clinically important lung-function measures: forced expiratory volume in the first …

Genome-wide association study of preserved ratio impaired spirometry (PRISm)

DH Higbee, A Lirio, F Hamilton… - European …, 2024 - Eur Respiratory Soc
… PRISm is a diagnosis based on spirometry, as opposed to a … based on spirometric criteria
has discovered loci that have … , as well as how spirometric measures are routinely used for …

Genome-wide linkage analysis of bronchodilator responsiveness and post-bronchodilator spirometric phenotypes in chronic obstructive pulmonary disease

LJ Palmer, JC Celedón, HA Chapman… - Human molecular …, 2003 - academic.oup.com
loci on chromosomes 2q and 8p, and further suggest that post-bronchodilator spirometric
measures are … This study has also identified several genomic regions that could contain loci