Sex differences in DNA methylation may contribute to risk of PTSD and depression: a review of existing evidence

M Uddin, L Sipahi, J Li, KC Koenen - Depression and anxiety, 2013 - Wiley Online Library
… least some of the heightened risk of PTSD onset in women (hypothesis (… risk for PTSD
following trauma,21 and this twofold increased risk of PTSD persists across a wide range of trauma

[HTML][HTML] The effects of trauma, with or without PTSD, on the transgenerational DNA methylation alterations in human offsprings

NA Youssef, L Lockwood, S Su, G Hao, BPF Rutten - Brain sciences, 2018 - mdpi.com
… While knowledge of possible epigenetic underpinnings of the association between
exposure to trauma and risk of PTSD has been discussed in several reviews, it remains to be …

Adverse childhood experience, genes, and PTSD risk in soldiers: a methylation study

MR Hossack, MW Reid, JK Aden, T Gibbons… - Military …, 2020 - academic.oup.com
DNA methylation patterns of multiple genes have been studied in both civilian populations
and military personnel with post-traumatic stress disorder (PTSD)… that the methylation levels of …

DNA methylation correlates of PTSD: Recent findings and technical challenges

FG Morrison, MW Miller, MW Logue, M Assef… - Progress in Neuro …, 2019 - Elsevier
… -dependent regulation of FKBP5 was associated with increased risk for adulthood stress-…
be selectively demethylated in risk allele carriers with childhood but not adult trauma. In in vitro …

[HTML][HTML] Blood-based DNA methylation and exposure risk scores predict PTSD with high accuracy in military and civilian cohorts

AH Wani, S Katrinli, X Zhao… - BMC Medical …, 2024 - bmcmedgenomics.biomedcentral …
risk for complex disorders such as PTSD. Our goal was to develop and validate Methylation
Risk Scores (MRS) using machine learning to distinguish individuals who have PTSD from …

DNA methylation signatures of childhood trauma predict psychiatric disorders and other adverse outcomes 17 years after exposure

CLJD van den Oord, WE Copeland, M Zhao… - Molecular …, 2022 - nature.com
… childhood trauma and DNA methylation [4]. Almost all studies link methylation changes in …
As cumulative trauma exposure seems a critical determinant of health risks [7], we summed …

[HTML][HTML] An epigenome-wide DNA methylation study of PTSD and depression in World Trade Center responders

PF Kuan, MA Waszczuk, R Kotov, CJ Marsit… - Translational …, 2017 - nature.com
… of PTSD and of MDD to date, investigating DNA methylation … We found no significant
genome-wide methylation differences … events on risk for posttraumatic stress disorder. Depress …

Epigenome-wide meta-analysis of PTSD symptom severity in three military cohorts implicates DNA methylation changes in genes involved in immune system and …

S Katrinli, AX Maihofer, AH Wani, JR Pfeiffer… - Molecular …, 2022 - nature.com
… is therefore a crucial step in deciphering mechanisms of risk and resilience. In this … PTSD
symptom severity (PTSS) and changes in PTSS over time, using whole blood DNA methylation (…

PTSD is associated with increased DNA methylation across regions of HLA-DPB1 and SPATC1L

S Katrinli, Y Zheng, A Gautam, R Hammamieh… - Brain, behavior, and …, 2021 - Elsevier
… Here we aimed to identify epigenetic differences associated with PTSD. DNA methylation
data … This study supports an emerging literature linking PTSD risk to genetic and epigenetic …

Accelerated DNA methylation age: associations with PTSD and neural integrity

EJ Wolf, MW Logue, JP Hayes, N Sadeh… - …, 2016 - Elsevier
Posttraumatic stress disorder (PTSD) has been identified as a chronic stress-related
condition that may accelerate cellular aging, increasing risk for neuronal cell death via oxidative …