… High-risk prostate cancer (PCa) is a potentially lethal disease. It is clinically important to
identify patients with high-risk PCa early on because they stand to benefit the most from curative …

… of prostate cancer. Together these data show an increased risk for the development of clinical
prostate cancer … It remains unclear if the current National Cancer Institute prostate cancer …

BACKGROUND: Overdiagnosis and subsequent overtreatment are important side effects of
screening for, and early detection of, prostate cancer (PCa). Active surveillance (AS) is of …

… cancer in the … prostate cancer if they live long enough. This review is a contemporary and
comprehensive, literature-based analysis of the putative risk factors for human prostate cancer, …

… Family history is also an important risk factor for prostate cancer, … the risk of prostate cancer
is profound, as is the frequency with which migrants from low- to high-risk areas adopt the risk …

… used to diagnose prostate cancer in the United States. Methods to integrate other risk
factors associated with prostate cancer into individualized risk prediction are needed. We used …

… incorporating established risk factors for prostate cancer in … prostate cancer, and prostate
volume, we were able to improve the positive predictive value of PSA to detect prostate cancer …

… of prostate cancer in families, and family history of prostate cancer remains one of the most
consistent risk … the existence of high-risk alleles for prostate cancer, and twin studies have …

… family history of prostate cancer and the risk of this cancer in a … Cases were all incident
cases of prostate cancer in men younger … Prostate cancer risk was increased among men who …

… and high risk prostate cancer at diagnosis, respectively. Figure 1 shows trends in the
distribution of patients among the risk groups. The proportion of patients at low risk almost doubled …