Statistical genetics and polygenic risk score for precision medicine
T Konuma, Y Okada - Inflammation and regeneration, 2021 - Springer
… Precision medicine can be defined as tailored medical care primarily based on … One of
the important approaches for precision medicine is stratifying individual genetic susceptibility …
the important approaches for precision medicine is stratifying individual genetic susceptibility …
Genetic risk scores for diabetes diagnosis and precision medicine
… utilization of polygenic scores within diabetes clinical practice is likely to be an important
component of efforts to deliver precision medicine for those who have, or are at risk for, diabetes …
component of efforts to deliver precision medicine for those who have, or are at risk for, diabetes …
The value of genetic risk scores in precision medicine for diabetes
MI McCarthy, A Mahajan - Expert Review of Precision Medicine …, 2018 - Taylor & Francis
… The comments above focused on the clinical value of risk scores that capture overall risk
of … risk per se: as we have seen, there are already well-established risk factors for T2D-risk …
of … risk per se: as we have seen, there are already well-established risk factors for T2D-risk …
Polygenic risk scores for breast cancer—Can they deliver on the promise of precision medicine?
PD Shah - JAMA Network Open, 2021 - jamanetwork.com
… This study advances the goals of precision medicine, which … in informing effective cancer
risk mitigation strategies, then … risk estimates; second, in what contexts are we applying these …
risk mitigation strategies, then … risk estimates; second, in what contexts are we applying these …
Risk factors and prevention of hepatocellular carcinoma in the era of precision medicine
… Thus, it seems sensible to consider preventing HCC development and progression in patients
at risk… tailoured preventive strategies based on cancer risk in the era of precision medicine. …
at risk… tailoured preventive strategies based on cancer risk in the era of precision medicine. …
[HTML][HTML] Machine learning SNP based prediction for precision medicine
… Here, we provide an overview of polygenic risk scoring and machine learning in complex
disease risk prediction. We highlight recent machine learning application developments and …
disease risk prediction. We highlight recent machine learning application developments and …
Risk scores for hepatocellular carcinoma in chronic hepatitis B: a promise for precision medicine
GV Papatheodoridis, T Voulgaris, M Papatheodoridi… - Hepatology, 2020 - journals.lww.com
… In this review, we conduct a thorough literature search for HCC risk scores in untreated and
… among these scores, we gain useful insights about how NA therapy affects the risk of HCC …
… among these scores, we gain useful insights about how NA therapy affects the risk of HCC …
The fistula risk score catalog: toward precision medicine for pancreatic fistula after pancreatoduodenectomy
MT Trudeau, F Casciani, BL Ecker, L Maggino… - Annals of …, 2022 - journals.lww.com
… However, risk-stratification using the FRS has never been … risk assessment could be
utilized for precision medicine … a practical way to approach precision medicine, allowing for …
utilized for precision medicine … a practical way to approach precision medicine, allowing for …
Cases in precision medicine: the role of polygenic risk scores in breast cancer risk assessment
N Zeinomar, WK Chung - Annals of internal medicine, 2021 - acpjournals.org
… risk scores (PRSs) have been consistently associated with elevated breast cancer risk in
cohort studies and are associated with risk in … in personalized risk assessment of breast cancer. …
cohort studies and are associated with risk in … in personalized risk assessment of breast cancer. …
Moving from clinical trials to precision medicine: the role for predictive modeling
MJ Pencina, ED Peterson - Jama, 2016 - jamanetwork.com
… Precision medicine calls for the customization of health care, with medical decisions tailored
to the individual patient. Sometimes precision medicine … risk score in an external sample. …
to the individual patient. Sometimes precision medicine … risk score in an external sample. …
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