… A potentially exciting future application may be that polygenic risk scores (PRSs) could be
used to predict outcomes for patients with IBD 40 ; however, this will first require much larger …

… While initial studies suggest that such risk perceptions are common across ancestry … of
precision medicine 43 . Future investigations are planned to deepen our understanding of risk …

… For precise molecular diagnoses of genetic diseases, we … as a step towards Precision
Medicine. The genetic architecture … We are now capable of obtaining Polygenic Risk Scores for all …

… among males 50–74 y of age was 39%; for women, the risk was lower but still substantial at
… disease risks associated with premature death (Fig. 1). Our objective for precision medicine …

… terms of risk discrimination 45) . A few years later, we showed that a polygenic risk score using
… useful as other traditional risk factors for risk discrimination 46) . Furthermore, a polygenic …

… gray zone between Gleason score 6 and score 7 tumors could account in part for the wide
distribution of molecular risk scores in individual clinical risk categories based on Gleason …

… risk estimations (CitationHunter 2016). This potential lack of clarity on risk despite the use of
precision medicine … Doctors need to understand the implications of these scores if they are to …

… has led to weaker risk scores related to kidney function. … personalized and precision medicine
prevention innovation at 2 … We think that precision medicine as applied to cardiovascular …

… risk factors. These new findings have opened up the possibility of precision medicine for …
3 (PNPLA3), a common and strong genetic risk factor for NASH (Section 4). We assess the …

… , providing information on noncoding regions and copy number variants and enabling
derivation of polygenic risk scores for complex traits. It is not routinely used in clinical practice. …