… factors to disease risk in different populations. The … risk scores in the context of multipollutants
(110, 111). More recently, studies have more broadly evaluated polyexposome scores …

… Risk scores such as the Framingham Risk Score were designed to be general scores
that could be used in any population and have been adopted even across different countries. …

… have been developed and why their use has been limited, if not unsuccessful, and we
discuss the characteristics of an “ideal CS risk score” and identify opportunities for future model …

… of cardiovascular disease using polygenic risk scores (PRS) that … an ability to identify risk
equivalent to monogenic mutations. 1 … placement of PRS in risk assessment and lipid treatment …

… Individuals with obesity ranked in the highest quartile for methylation risk score had a tenfold
increased risk of developing type 2 diabetes mellitus compared with those ranked in the …

… Some further general concerns apply to the use of environmental risk scores, some of which
also apply for genetic risk scores. These concerns include the stability and accuracy of effect …

… A further concern is that despite the fact that CVD risk scores have good accuracy in predicting
CVD risk [31], prediction of future CVD events is less reliable at the individual level [32]. …

… Despite numerous available modalities (quantitative and qualitative) of risk communication,
consensus over the advantage of any single modality in translating evidence into risk …

… of a multifactorial risk … risk score and CAD 50 for the remaining aspects of risk assessment
(ie, the collection of questionnaire-based risk factors, breast density and the estimation of risk …

… of low-risk individuals. Furthermore, individuals whose risk scores are just below the risk-…
should be given guidance on whether and when reassessment of their risk should occur. …