Principles and methods for transferring polygenic risk scores across global populations
…, Polygenic Risk Methods in Diverse Populations … - Nature Reviews …, 2024 - nature.com
… to integrate data from diverse populations, enabling more powerful analyses of … populations
5 . Here, we consider the principles and methods of applying PRSs across global populations…
5 . Here, we consider the principles and methods of applying PRSs across global populations…
Comparison of nonblood-based and blood-based total CV risk scores in global populations
TA Gaziano, S Abrahams-Gessel, S Alam, D Alam… - Global heart, 2016 - Elsevier
… the CVD risk score identified 15% of the population above this risk threshold, then we used
the equivalent risk threshold of the Harvard NHANES score to identify 15% of the population. …
the equivalent risk threshold of the Harvard NHANES score to identify 15% of the population. …
A novel risk score to predict cardiovascular disease risk in national populations (Globorisk): a pooled analysis of prospective cohorts and health examination surveys
… Comparison of the Framingham and Reynolds Risk scores for global cardiovascular risk …
Application in national populations We used the risk score to estimate the 10-year risk of fatal …
Application in national populations We used the risk score to estimate the 10-year risk of fatal …
Clinical use of current polygenic risk scores may exacerbate health disparities
… pressure in all populations. In contrast, other effects on polygenic adaptation or risk
scores, such as long-standing environmental differences across global populations that have …
scores, such as long-standing environmental differences across global populations that have …
[HTML][HTML] Genetic disease risks can be misestimated across global populations
… sequence data from global populations with results from … of how disease risks can be
misestimated in global populations, and (3… genetic risk scores that correct for major sources of …
misestimated in global populations, and (3… genetic risk scores that correct for major sources of …
Risk scores for type 2 diabetes can be applied in some populations but not all
C GLumer, D Vistisen, K Borch-Johnsen… - Diabetes …, 2006 - Am Diabetes Assoc
… risk factors on having undiagnosed type 2 diabetes differs between populations from different
ethnic origin, and risk scores … of one risk score in nine populations of diverse ethnic origin. …
ethnic origin, and risk scores … of one risk score in nine populations of diverse ethnic origin. …
Risk scores for type 2 diabetes mellitus in Latin America: a systematic review of population‐based studies
RM Carrillo‐Larco, DJ Aparcana‐Granda… - Diabetic …, 2019 - Wiley Online Library
… Although there have been previous efforts to synthesize available risk scores globally 9-12, …
risk scores for Latin American populations. In so doing, we provide a list of risk scores that …
risk scores for Latin American populations. In so doing, we provide a list of risk scores that …
[PDF][PDF] Global Biobank analyses provide lessons for developing polygenic risk scores across diverse cohorts
… Polygenic risk scores (PRSs) have been widely explored in precision medicine. However, …
in global populations across different diseases. We here utilized data from Global Biobank …
in global populations across different diseases. We here utilized data from Global Biobank …
[HTML][HTML] Analysis of polygenic risk score usage and performance in diverse human populations
… in score distributions for global populations. Polygenic … of polygenic risk scores is poorer in
non-European populations, … genetic diversity within many African populations, the phenotypic …
non-European populations, … genetic diversity within many African populations, the phenotypic …
Development and validation of improved algorithms for the assessment of global cardiovascular risk in women: the Reynolds Risk Score
PM Ridker, JE Buring, N Rifai, NR Cook - Jama, 2007 - jamanetwork.com
… risk in a currently healthy population. Equally important, that analysis relied on data from
1712 women who experienced only 68 vascular events, many of which were coded as heart …
1712 women who experienced only 68 vascular events, many of which were coded as heart …
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