… or decreased risk for hundreds of complex disorders. For a given disease, SNPs can be
combined to generate a cumulative estimation of risk known as a polygenic risk score (PRS). …

… and targets to inform optimal use of statins in the primary … ) are risk modifiers in calculating
the risk score with the new … hsCRP in the reclassification of CVD risk, and the concept of …

… risk factors for ASCVD, and these risk factors will need to be validated across the traditional
cohorts. However, risk score derivation and validation must make use … , risk scores could be …

… In this Perspective, we therefore outline the Task Force’s understanding of the … risk score
may augment the risk conferred by a high-impact mutation, or a protective polygenic risk score …

… Clinical use of polygenic risk scores (PRS) will look very different to the more familiar
monogenic testing. Here we argue that despite these differences, most of the ethical, legal, and …

… This included the use of risk scores as a counseling instrument, an educational tool, a … the
use of currently existing risk scores. From their perspective, the introduction of risk scores into …

… on the use of the disease risk score in epidemiology, … this score, and illustrate the development
of a disease risk score … , compared with the perspective provided by construction of a …

… based risk-scoring systems, using the Framingham Risk Score … of this approach for use
in the presence of competing risk. We … and computing perspective, such points-based risk-scoring …

… that motivate why we want to use a cutting plane algorithm to solve the risk score problem:
(i) Scalability in the Sample Size: Cutting plane algorithms use the training data only when …

… approaches that use multivariate algorithms to improve personalized risk level assessment.
Such … We draw on our experience from the PERSPECTIVE I&I breast cancer project. This “…