Prostate cancer (PCa) risk variants and risk of fatal PCa in the national cancer institute breast and prostate cancer cohort consortium

IM Shui, S Lindström, AS Kibel, SI Berndt, D Campa… - European urology, 2014 - Elsevier
… In this report, we assessed whether established PCa risk variants could predict PCSM. We
found eight risk variants associated with PCSM: One predicted an increased risk of PCSM, …

Association of prostate cancer risk variants with gene expression in normal and tumor tissue

KL Penney, JA Sinnott, S Tyekucheva, T Gerke… - Cancer epidemiology …, 2015 - AACR
… genetic variants are associated with prostate cancer risk, … variants influence gene expression
in prostate tissue. We therefore examined the association of prostate cancer risk variants

Association of prostate cancer risk variants with clinicopathologic characteristics of the disease

J Xu, SD Isaacs, J Sun, G Li, KE Wiley, Y Zhu… - Clinical Cancer …, 2008 - AACR
variants with clinicopathologic variables of prostate cancer, we systematical evaluated all
prostate cancer risk variants … prostatectomy for treatment of prostate cancer at Johns Hopkins …

A large multiethnic genome-wide association study of prostate cancer identifies novel risk variants and substantial ethnic differences

TJ Hoffmann, SK Van Den Eeden, LC Sakoda… - Cancer discovery, 2015 - AACR
… new risk variants for prostate cancer, confirm many previously reported associations at
various levels across ethnic groups, and provide independent evidence that additional risk SNPs …

Genetic variants associated with predisposition to prostate cancer and potential clinical implications

CL Goh, FR Schumacher, D Easton… - Journal of internal …, 2012 - Wiley Online Library
… Several studies have explored the capacity of established prostate cancer risk variants to
differentiate between the less aggressive and more aggressive disease. Somatic genetic …

Combined effect of a polygenic risk score and rare genetic variants on prostate cancer risk

BF Darst, X Sheng, RA Eeles, Z Kote-Jarai, DV Conti… - European urology, 2021 - Elsevier
… UK Biobank, including 3568 prostate cancer cases, to examine … variants and common
prostate cancer risk variants, measured using a polygenic risk score (PRS), on prostate cancer risk

[HTML][HTML] Germline genetics of prostate cancer: prevalence of risk variants and clinical implications for disease management

DK Doan, KT Schmidt, CH Chau, WD Figg - Cancers, 2021 - mdpi.com
… of the molecular basis of prostate cancer have resulted in the … variants that places them at
increased risk of developing the disease. The goal of precision oncology in prostate cancer is …

[PDF][PDF] Five genetic variants associated with prostate cancer

RJ Coates, MJ Khoury, M Gwinn - N Engl J Med, 2008 - academia.edu
… With 10 additional risk variants reported since February 2008, it is expected that the sensitivity
and specificity will be further improved. We do not advocate replacing the PSA test with …

Sequence variants at 22q13 are associated with prostate cancer risk

J Sun, SL Zheng, F Wiklund, SD Isaacs, G Li, KE Wiley… - Cancer research, 2009 - AACR
… The goal of this study is to search for these risk variants using existing data from two GWAS:
risk variants that are associated with more clinically relevant, aggressive prostate cancer, we …

Individual and cumulative effect of prostate cancer risk‐associated variants on clinicopathologic variables in 5,895 prostate cancer patients

AK Kader, J Sun, SD Isaacs, KE Wiley, G Yan… - … Prostate, 2009 - Wiley Online Library
… (SNPs) have been associated with prostate cancer (PCa) risk from genome-wide association
… Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects …