[HTML][HTML] Potential application of sucrose acetate isobutyrate, and glyceryl monooleate for nanonization and bioavailability enhancement of rivaroxaban tablets

AA Al-Shoubki, MH Teaima, R Abdelmonem… - Pharmaceutical Science …, 2024 - Elsevier
Glyceryl monooleate (GMO) as co-formers for creating Cubosomes and SAIB-based
nanodispersions of Rivaroxaban … improved drug release compared to XARELTO®. L4 displayed …

Sucrose acetate isobutyrate (SAIB) and glyceryl monooleate (GMO) hybrid nanoparticles for bioavailability enhancement of rivaroxaban: an optimization study

AA Al-Shoubki, MH Teaima… - Pharmaceutical …, 2023 - Taylor & Francis
… We conducted weight variation, hardness, and friability tests on RXB and Xarelto tablets to
… that the Xarelto tablets had a weight variation of (1.59% ±0.18), while the L4 tablets had a …

Quality-by-design-based development of Rivaroxaban-Loaded Liquisolid Compact tablets with Improved Biopharmaceutical attributes

P Shah, H Desai, B Vyas, M Lalan, M Kulkarni - AAPS PharmSciTech, 2023 - Springer
… immediate-release tablets, Xarelto tablets, and RXN LSC-based tablets were performed …
Neat RXN/immediate-release tablets/Xarelto tablets/RXN LSC-based tablets (containing 10 …

Experimental design, formulation, and in-vivo evaluation of novel anticoagulant Rivaroxaban loaded cubosomes in rats model

HA El-Hashemy, A Salama… - Journal of Liposome …, 2023 - Taylor & Francis
… A novel oral anticoagulant drug named Rivaroxaban ‘RX’ will be studied in this research …
We evaluated the effects of drug concentration, poloxamer to glyceryl monooleate ratio, and …

[PDF][PDF] Pharmaceutical Science Advances

AA Al-Shoubki, MH Teaima, R Abdelmonem… - researchgate.net
… use of Sucrose acetate isobutyrate (SAIB) and Glyceryl monooleate (GMO) as co-formers
for creating Cubosomes and SAIB-based nanodispersions of Rivaroxaban (RXB). The process …

[HTML][HTML] Quality-by-Design-Driven Nanostructured Lipid Scaffold of Apixaban: Optimization, Characterization, and Pharmacokinetic Evaluation

K Patil, N Gujarathi, C Sharma, S Ojha, S Goyal… - Pharmaceutics, 2024 - mdpi.com
… as Apixaban and Rivaroxaban have gained significant attention for their effectiveness in
preventing and treating thromboembolic disorders. Both Apixaban and Rivaroxaban have been …

[PDF][PDF] Apixaban ultrafine O/W nano emulsion transdermal drug delivery system: formulation, in vitro and ex vivo characterization

MR Abdulbaqi, NA Rajab - Systematic Reviews in Pharmacy, 2020 - researchgate.net
Apixaban (APX) is a potent oral anticoagulant drug that directly inhibit coagulation factor Xa
for prevention of venous thromboembolism (VTE) following total hip or knee replacement …

[HTML][HTML] In Vitro Lipolysis Model to Predict Food Effect of Poorly Water-Soluble Drugs Itraconazole, Rivaroxaban, and Ritonavir

RP Patel, R Cristofoletti, F Wu, A Al Shoyaib… - Journal of …, 2024 - Elsevier
… Meanwhile, biorelevant media such as Fed State Simulated Intestinal Fluid (FeSSIF-V2)
includes fatty acid (ie, oleic acid) and monoglyceride (eg, glycerol monooleate), although is not …

Recent advances in anticoagulant drug delivery

J Park, Y Byun - Expert Opinion on Drug Delivery, 2016 - Taylor & Francis
… For direct Fxa inhibitors, rivaroxaban and apixaban were widely prescribed for patients with
… delivery of enoxaparin, which used chitosan graft glyceryl monooleate (CS–GO), was also …

Functional Excipients and Novel Drug Delivery Scenario in Self-nanoemulsifying Drug Delivery System: A Critical Note

R Tonjan, D Singh - Pharmaceutical Nanotechnology, 2022 - ingentaconnect.com
Lipid-based formulations have emerged as prospective dosage forms for extracting the
therapeutic effects of existing lipophilic compounds and novel chemical entities more efficiently. …