On the edge of degradation: autophagy regulation by RNA decay

E Delorme‐Axford, DJ Klionsky - … Reviews: RNA, 2019 - Wiley Online Library
… and regulate appropriate levels … decay machinery as novel regulators of autophagy. Here,
we review current findings that demonstrate how autophagy is modulated through RNA decay. …

The autophagyRNA interplay: degradation and beyond

MH Abildgaard, SH Brynjólfsdóttir, LB Frankel - Trends in Biochemical …, 2020 - cell.com
… , rely on autophagy for their degradation in response to various conditions of cellular
stress. Autophagy-mediated RNA decay may complement more well-described RNA quality-control …

Inhibition of nonsense-mediated RNA decay activates autophagy

J Wengrod, L Martin, D Wang… - … and cellular biology, 2013 - Am Soc Microbiol
… of autophagosomes is the gold standard for autophagy, and we noted that Upf1/Rent1
depletion in U2OS cells also led to double-membraned vesicles, consistent with autophagosomes

Emerging connections between RNA and autophagy

LB Frankel, M Lubas, AH Lund - Autophagy, 2017 - Taylor & Francis
… of core autophagy regulation mediated by RNA-binding proteins and noncoding RNAs, and
point … , because not only can autophagosomes contribute to viral RNA decay, but conversely, …

The connection between ribophagy, autophagy and ribosomal RNA decay

GC MacIntosh, DC Bassham - Autophagy, 2011 - Taylor & Francis
… RNS2, a conserved member of the RNase T2 family, is necessary for ribosomal RNA
decay in plants. Proc Natl Acad Sci USA 2011; 108:1093–8; PMID: 21199950; DOI: 10.1073/pnas.…

Post-transcriptional dynamics and RNA homeostasis in autophagy and cancer

SP Kolapalli, TM Nielsen, LB Frankel - Cell Death & Differentiation, 2023 - nature.com
… Further, we review new insight toward autophagy regulation … The crucial balance between
RNA production and decay … , our understanding of RNA decay pathways remains more …

A conserved mechanism of TOR-dependent RCK-mediated mRNA degradation regulates autophagy

G Hu, T McQuiston, A Bernard, YD Park, J Qiu… - Nature cell …, 2015 - nature.com
Autophagy is an essential eukaryotic pathway requiring tight regulation to maintain … we
report a conserved mechanism of autophagy regulation by RNA helicase RCK family members in …

[HTML][HTML] LC3B is an RNA-binding protein to trigger rapid mRNA degradation during autophagy

HJ Hwang, H Ha, BS Lee, BH Kim, HK Song… - Nature …, 2022 - nature.com
… of PRMT1 mRNA by LC3B facilitates autophagy. Collectively, we demonstrate that LC3B
acts as an RNA-binding protein and an mRNA decay factor necessary for efficient autophagy. …

Stress and the nonsense-mediated RNA decay pathway

AE Goetz, M Wilkinson - Cellular and Molecular Life Sciences, 2017 - Springer
… Recent work has demonstrated that a conserved and highly selective RNA degradation
pathway—nonsense-mediated RNA decay (NMD)—serves as a major regulator of the UPR …

Differential degradation of RNA species by autophagy-related pathways in Arabidopsis

D Hickl, F Drews, C Girke, D Zimmer… - Journal of …, 2021 - academic.oup.com
… obtain information about the types of RNAs present at single nucleotide … autophagy process
(ATG5) or RNA catabolism (RNS2) in our analysis. In addition, sequencing of cellular RNAs