[HTML][HTML] CRISPR/Cas system: recent advances and future prospects for genome editing

H Manghwar, K Lindsey, X Zhang, S Jin - Trends in plant science, 2019 - cell.com
… ] reported a C to U RNA editor referred to as RNA Editing for Specific C to U Exchange (…
number of pathogenic mutations targetable by RNA editing and enables modification of phospho-…

[HTML][HTML] The CRISPR/Cas genome-editing tool: application in improvement of crops

S Khatodia, K Bhatotia, N Passricha… - Frontiers in plant …, 2016 - frontiersin.org
… The elucidation of the CRISPR-Cas9 mechanism have resulted in many fundamental
discoveries in biology (Doudna and Charpentier, 2014). CRISPR/Cas genome editing as a …

Engineered extracellular vesicle‐delivered CRISPR/CasRx as a novel RNA editing tool

T Li, L Zhang, T Lu, T Zhu, C Feng, N Gao… - Advanced …, 2023 - Wiley Online Library
… -associated 9 (Cas9) delivered by EVs enable efficient DNA editing. However, an RNA editing
tool … In summary, a potent tool is provided for short-acting RNA editing, which could be a …

REDIportal: millions of novel A-to-I RNA editing events from thousands of RNAseq experiments

L Mansi, MA Tangaro, C Lo Giudice, T Flati… - Nucleic acids …, 2021 - academic.oup.com
RNA editing has pivotal roles in the regulation of gene expression or … the RNA editing
biology are still unknown and need to be elucidated. To support the study of A-to-I RNA editing we …

Genome editing with CRISPRCas nucleases, base editors, transposases and prime editors

AV Anzalone, LW Koblan, DR Liu - Nature biotechnology, 2020 - nature.com
… Finally, we summarize emerging CRISPRCas genome editing tools, including Cas … copy
edited sequences into target DNA sites in a manner that replaces the original DNA sequence. …

The new CRISPRCas system: RNA-guided genome engineering to efficiently produce any desired genetic alteration in animals

D Seruggia, L Montoliu - Transgenic research, 2014 - Springer
… distinct applications of CRISPRCas technology for … editing nucleases. We will guide
the reader through the many publications that have seen the light in the first year of CRISPRCas

[HTML][HTML] Preventing autosomal-dominant hearing loss in Bth mice with CRISPR/CasRx-based RNA editing

Z Zheng, G Li, C Cui, F Wang, X Wang, Z Xu… - … and Targeted Therapy, 2022 - nature.com
RNAs, which is a promising treatment for various disorders by downregulation of related
gene expression. Here, we tested this RNA-editing … the CRISPR/CasRx-based RNA editing

History of CRISPR-Cas from encounter with a mysterious repeated sequence to genome editing technology

Y Ishino, M Krupovic, P Forterre - Journal of bacteriology, 2018 - Am Soc Microbiol
… the CRISPR-Cas system and to our understanding of its function and mode of action (for
other recent reviews on the history of the research on the CRISPR-Cas system, see references 9…

Delivery aspects of CRISPR/Cas for in vivo genome editing

D Wilbie, J Walther, E Mastrobattista - Accounts of chemical …, 2019 - ACS Publications
… status of in vivo CRISPR/Cas delivery with both synthetic and viral vectors and will focus
on the differences in delivery methods in terms of on-target genome editing efficiency and off-…

CRISPR/Cas13: a novel and emerging tool for RNA editing in plants

D Pandita, COR Puli, SR Palakolanu - RNA-Based Technologies for …, 2021 - Springer
… The engineered Cas13 can also be used for programmable RNA editing. The high …
CRISPR/Cas system including its discovery and origin, mechanism, and role of Cas13 in RNA