… the comparability of hepatotoxicity marker testing at the mRNA and protein levels in HepaRG
… of their toxicity. Furthermore, a number of robust hepatotoxicity marker genes and proteins …

… markers in medicine, circulating RNA molecules have become appealing biomarker candidates
in liver disease. … assessment and interpretation of circulating RNA levels imposes a more …

… can identify toxicity markers from expressed proteins in cultured cells. Potential marker proteins
are … altered in their concentration through the action of toxic compounds. The change of …

… However, the identification of markers of human disease and … requirement for ribonucleic
acid (RNA) from tissue samples … promise in identifying clinically useful markers but has been …

… This proof of principle study demonstrated the ability to develop a robust, high throughput,
customizable SRM assay to evaluate putative protein markers of hepatotoxicity. …

… potential liver toxicity genomic biomarkers from a liver toxicity … (“non-liver toxic drug”) and
tolcapone (“hepatotoxic drug”). … RNA was isolated from the frozen liver powder aliquots in …

… To obtain the gene-level changes in the liver and kidney, we analyzed the raw RNA-seq
data collected from rats exposed to a single dose of APAP (2 g/kg) and observed for 5 h or 10 h …

… markers, and their potential role in assessing the presence and severity of liver damage in
… membrane, cytosolic and nuclear proteins, and RNAs including miRNAs from parental cells …

… RNA isolation, processing and hybridization were essentially … RNA was extracted from 274
liver tissues, processed and … robust and informative markers of liver damage. These organic …

… in the space of gene transcripts, proteins, and metabolites/small molecules. In this article,
we present the results for the liver and plasma markers discovered across the same set of …