Biomolecular condensates: new opportunities for drug discovery and RNA therapeutics
BA Conti, M Oppikofer - Trends in Pharmacological Sciences, 2022 - cell.com
… be leveraged for new therapeutic approaches. We also discuss how condensates may aid
… biomolecular condensates and RNA therapeutics to deliver novel opportunities for patients. …
… biomolecular condensates and RNA therapeutics to deliver novel opportunities for patients. …
What are the distinguishing features and size requirements of biomolecular condensates and their implications for RNA-containing condensates?
JD Forman-Kay, JA Ditlev, ML Nosella, HO Lee - RNA, 2022 - rnajournal.cshlp.org
… , such as transcription, RNA processing, and translation (… RNA biology, here we focus on
biomolecular condensates containing RNA and protein, such as “transcriptional condensates…
biomolecular condensates containing RNA and protein, such as “transcriptional condensates…
Biomolecular condensates and cancer
… and RNA molecules with related functions. New insights from … key features of biomolecular
condensates, note where they … cancer therapeutics can be greatly influenced by condensates, …
condensates, note where they … cancer therapeutics can be greatly influenced by condensates, …
Modulating biomolecular condensates: a novel approach to drug discovery
… community within condensates provides an untapped source of therapeutic agents. Notably,
… Similarly, helicase action controls the partitioning of RNA within biomolecular condensates …
… Similarly, helicase action controls the partitioning of RNA within biomolecular condensates …
A framework for understanding the functions of biomolecular condensates across scales
AS Lyon, WB Peeples, MK Rosen - Nature Reviews Molecular Cell …, 2021 - nature.com
… The best-studied example of vectoral organization of biochemistry via biomolecular
condensation is the production of ribosomes in the nucleolus, where pre-ribosomal RNA is …
condensation is the production of ribosomes in the nucleolus, where pre-ribosomal RNA is …
Biomolecular condensates pique drug discovery curiosity
A Mullard - Nat. Rev. Drug Discov, 2019 - nature.com
… of biomolecular condensates — transient liquid-like droplets made up of proteins and RNA
— is … “Depending on the specific therapeutic situation and the specific target and the specific …
— is … “Depending on the specific therapeutic situation and the specific target and the specific …
Biomolecular condensates in cancer biology
HI Suzuki, K Onimaru - Cancer Science, 2022 - Wiley Online Library
… the possibility of therapeutic targeting of condensates. This … and biomolecular condensate
models, multiple scenarios of … between condensate components, such as protein, RNA, and …
models, multiple scenarios of … between condensate components, such as protein, RNA, and …
Insights from biomolecular condensates into disease and drug development
LK Afeyan - 2022 - dspace.mit.edu
… nucleic acid-based therapeutics targeting RNA, partition into and modulate certain …
biomolecular condensates to facilitate the development of novel disease mechanistic and …
biomolecular condensates to facilitate the development of novel disease mechanistic and …
[HTML][HTML] Designer condensates: a toolkit for the biomolecular architect
RL Hastings, S Boeynaems - Journal of Molecular Biology, 2021 - Elsevier
… as tools for potential drug or gene therapy delivery. The recent advances in generating …
out what makes specific proteins and RNAs partition into condensates in vivo. Since in vivo …
out what makes specific proteins and RNAs partition into condensates in vivo. Since in vivo …
Biomolecular condensates in the nucleus
… Further understanding of condensates may provide new therapeutic opportunities for … occur
within condensates that compartmentalize and concentrate the protein and RNA molecules …
within condensates that compartmentalize and concentrate the protein and RNA molecules …
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