Long non-coding RNA TUG1 promotes the osteogenic differentiation of bone marrow mesenchymal stem cells by regulating the AMPK/mTOR/autophagy pathway

DG Lu, MJ Lu, SH Yao, JJ Lin, S Luo, JH Wei… - Biomedical …, 2021 - jstage.jst.go.jp
… of lncRNA TUG1 during osteogenic induction in BMSCs. Furthermore, we explored whether
lncRNA TUG1 regulated osteogenesis via activation of the AMPK/mTOR/autophagy axis. …

[HTML][HTML] Long noncoding RNA TUG1 inhibits osteogenesis of bone marrow mesenchymal stem cells via Smad5 after irradiation

W Zhang, LI Chen, J Wu, J Li, X Zhang, Y Xiang, F Li… - Theranostics, 2019 - ncbi.nlm.nih.gov
… a high possibility that TUG1 binds to the MH1 domain of Smad5 (Figure ​3B). To test whether
TUG1 binds to Smad5, we performed a RIP assay and found that TUG1 RNA levels were …

lncRNA TUG1 facilitates colorectal cancer stem cell characteristics and chemoresistance by enhancing GATA6 protein stability

J Sun, H Zhou, X Bao, Y Wu, H Jia… - Stem cells …, 2021 - Wiley Online Library
RNA (lncRNA) TUG1 was highly expressed in CRC stem … that lncRNA TUG1 was elevated
in CRC stem cells and lncRNA TUG1 … and chemoresistance of CRC stem cells, and we further …

Long noncoding RNA TUG1 facilitates osteogenic differentiation of periodontal ligament stem cells via interacting with Lin28A

Q He, S Yang, X Gu, M Li, C Wang, F Wei - Cell Death & Disease, 2018 - nature.com
… ligament stem cells (PDLSCs) are mesenchymal stem cells … Recently, long noncoding RNAs
(lncRNAs) have been … In this study, we found that taurine upregulated gene 1 (TUG1), an …

Targeting the Notch-regulated non-coding RNA TUG1 for glioma treatment

K Katsushima, A Natsume, F Ohka, K Shinjo… - Nature …, 2016 - nature.com
TUG1 is an effective epigenetic modulator that regulates the cancer stem cell population. …
roles of nuclear-localized TUG1 in GSCs, we first transfected TUG1 RNA labelled with 5′-…

Long noncoding RNA TUG1 promotes osteogenic differentiation of human periodontal ligament stem cell through sponging microRNA-222-3p to negatively regulate …

D Wu, L Yin, D Sun, F Wang, Q Wu, Q Xu, B Xin - Archives of Oral Biology, 2020 - Elsevier
RNA and miRNA, we arranged this study to probe whether long noncoding RNA TUG1
was engaged in the osteogenic differentiation of human periodontal ligament stem cells

The long non-coding RNA TUG1 indicates a poor prognosis for colorectal cancer and promotes metastasis by affecting epithelial-mesenchymal transition

J Sun, C Ding, Z Yang, T Liu, X Zhang, C Zhao… - Journal of translational …, 2016 - Springer
… , immune surveillance, or embryonic stem cell pluripotency. Recently, evidence revealing
the molecular mechanisms by which these RNA species function has provided some insight …

Upregulation of the long noncoding RNA TUG1 promotes proliferation and migration of esophageal squamous cell carcinoma

Y Xu, J Wang, M Qiu, L Xu, M Li, F Jiang, R Yin, L Xu - Tumor Biology, 2015 - Springer
… Further, in vitro silencing TUG1 via siRNA … cells and blocked the progression of cell cycle.
Therefore, our study indicates that TUG1 promotes proliferation and migration of ESCC cells

Long non‐coding RNA TUG 1 promotes migration and invasion by acting as a ce RNA of miR‐335‐5p in osteosarcoma cells

Y Wang, T Yang, Z Zhang, M Lu, W Zhao… - Cancer …, 2017 - Wiley Online Library
stem cell differentiation and chromatin remodeling.7-10 Taurine upregulated gene 1 (TUG1) …
response to taurine treatment of developing mouse retinal cells and is mostly reported as an …

[HTML][HTML] lncRNA TUG1 inhibits the cancer stem cell‑like properties of temozolomide‑resistant glioma cells by interacting with EZH2

Y Cao, W Chai, Y Wang, D Tang… - Molecular …, 2021 - spandidos-publications.com
… Cancer stem cells (CSCs) have recently been determined to … have shown that long non‑coding
RNAs (lncRNAs) exert an … that taurine upregulated gene 1 (TUG1) exhibits an important …