A translational rodent assay of affective biases in depression and antidepressant therapy

SA Stuart, P Butler, MR Munafo, DJ Nutt… - …, 2013 - nature.com
… evaluation of an affective bias test (ABT) for rats designed to test the hypothesis that drugs
with acute effects on affective bias in human will have the same effects in rodents (Figure 1a). …

Modelling cognitive affective biases in major depressive disorder using rodents

CA Hales, SA Stuart, MH Anderson… - British journal of …, 2014 - Wiley Online Library
… Taken together with the effects of these treatments in human volunteers and patients,
these studies suggest that the rodent affective bias test predicts both antidepressant and pro-…

Affective biases and their interaction with other reward-related deficits in rodent models of psychiatric disorders

LR Lewis, A Benn, DM Dwyer, ESJ Robinson - Behavioural Brain Research, 2019 - Elsevier
affective biases in the context of other reward-related deficits and examine how affective
biases … these selective behavioural assays and the neurobiological mechanisms for affective

The Affective Bias Test and Reward Learning Assay: Neuropsychological Models for Depression Research and Investigating Antidepressant Treatments in Rodents

JK Hinchcliffe, ESJ Robinson - Current Protocols, 2024 - Wiley Online Library
… positive bias during the choice test. The affective bias test was developed to quantify
affective biases in rodents by generating two independent memories learned under either an …

Looking on the bright side of bias—Validation of an affective bias test for laboratory mice

DM Graulich, S Kaiser, N Sachser… - Applied Animal Behaviour …, 2016 - Elsevier
affective bias task for the use with laboratory mice. Similarities in behavioural responses
between rats and mice indicate the potential of the testing … in laboratory rodents and support the …

Affective biases in humans and animals

ESJ Robinson, JP Roiser - Translational neuropsychopharmacology, 2016 - Springer
… This clinical work into affective biases has also … of assays to study affective biases in rodents.
These animal studies suggest that, similar to humans, rodents in putative negative affective

Further validation of the affective bias test for predicting antidepressant and pro-depressant risk: effects of pharmacological and social manipulations in male and …

JK Hinchcliffe, SA Stuart, M Mendl, ESJ Robinson - Psychopharmacology, 2017 - Springer
… We have previously found that affective biases, associated with learning and memory, are …
test if similar biases are observed in male and female Sprague Dawley (SD) rats. We also test

Using the affective bias test to predict drug‐induced negative affect: implications for drug safety

SA Stuart, CM Wood… - British journal of …, 2017 - Wiley Online Library
… We investigated whether the affective bias test (ABT) could … A bias is observed during a
preference test when an animal's … an affective bias or reward‐induced positive bias respectively. …

Investigating hormone-induced changes in affective state using the affective bias test in male and female rats

JK Hinchcliffe, M Mendl, ESJ Robinson - Psychoneuroendocrinology, 2020 - Elsevier
assays designed to measure biases in learning and memory or decision-making. Given the
proposed links between hormones and mood, we used the affective bias test … in rodents and …

Translational new approaches for investigating mood disorders in rodents and what they may reveal about the underlying neurobiology of major depressive disorder

ESJ Robinson - … Transactions of the Royal Society B …, 2018 - royalsocietypublishing.org
… mechanism involving affective biases plays a … the affective bias test (ABT) [56,57]. This task
uses associative learning between a specific cue and reward to test the influence of affective