Animal models of acute lung injury

G Matute-Bello, CW Frevert… - … of Physiology-Lung …, 2008 - journals.physiology.org
… the pulmonary host response to noxious stimuli. We emphasize those models of lung injury
… disadvantages of each model and the extent to which each model reproduces human ARDS. …

Variable tidal volume ventilation improves lung mechanics and gas exchange in a rodent model of acute lung injury

SP Arold, R Mora, KR Lutchen… - … journal of respiratory …, 2002 - atsjournals.org
… ) to improve lung mechanics and oxygenation in the setting of acute lung injury depends on
… test this hypothesis we compared lung mechanics as well as blood oxygenation in a rodent

Lung and brainstem cytokine levels are associated with breathing pattern changes in a rodent model of acute lung injury

FJ Jacono, CA Mayer, YH Hsieh, CG Wilson… - Respiratory physiology & …, 2011 - Elsevier
… We conclude that breathing pattern changes in acute lung injury were associated with
increased levels of IL-1β in brainstem areas which integrate cardio-respiratory sensory input. …

Human models of acute lung injury

AG Proudfoot, DF McAuley… - Disease models & …, 2011 - journals.biologists.com
… In this article, we consider the clinical features of ALI, discuss the limitations of current
animal models and highlight how emerging human models of ALI might help to answer …

Using a non-invasive assessment of lung injury in a murine model of acute lung injury

S Lax, MR Wilson, M Takata… - BMJ Open Respiratory …, 2014 - bmjopenrespres.bmj.com
… multiple quantitative markers of lung injury and inflammation alongside non-invasive
monitoring of cardiopulmonary parameters during a mouse model of ALI. Our data revealed that …

Role of TNF-α in lung tight junction alteration in mouse model of acute lung inflammation

E Mazzon, S Cuzzocrea - Respiratory research, 2007 - Springer
… functional alterations in pulmonary TJ function in vivo as a result of acute lung inflammation
induced by carrageenan in mice. Herein, we demonstrate that acute lung injury is associated …

Endothelial cell-specific anticoagulation reduces inflammation in a mouse model of acute lung injury

J Lou, Y Hu, M Wu, L Che, Y Wu, Y Zhao… - Acta Pharmacologica …, 2019 - nature.com
lung inflammation and the pathogenesis of acute lung injury (ALI). In this study, we explored
the roles of targeted endothelial anticoagulation in ALI using two strains of transgenic mice

… inflammation in rats following exposure to combustion products of carbon–graphite/epoxy composite material: comparison to a rodent model of acute lung injury

GS Whitehead, KA Grasman, EC Kimmel - Toxicology, 2003 - Elsevier
Pulmonary function and inflammation in the lungs of rodents … to that of a rodent model of
acute lung injury (ALI) produced … mechanisms of a model of lung vascular injury. We examined …

Anti-inflammatory and anti-fibrotic treatment in a rodent model of acute lung injury induced by sulfur dioxide

E Wigenstam, L Elfsmark, L Ågren, C Akfur… - Clinical …, 2018 - Taylor & Francis
… In this study, we employed a rat model of SO 2 -induced lung injury suitable for studying …
pulmonary fibrosis. An animal ventilator and a forced oscillation method were used to evaluate …

Mouse models of acute respiratory distress syndrome: a review of analytical approaches, pathologic features, and common measurements

F Aeffner, B Bolon, IC Davis - Toxicologic pathology, 2015 - journals.sagepub.com
Lung injury scoring system adapted for mouse models of ARDS. … for common lesion scores
observed in mouse models of acute respiratory distress syndrome (ARDS). (A) Normal lung (…