Animal models of acute lung injury
G Matute-Bello, CW Frevert… - … of Physiology-Lung …, 2008 - journals.physiology.org
… the pulmonary host response to noxious stimuli. We emphasize those models of lung injury
… disadvantages of each model and the extent to which each model reproduces human ARDS. …
… disadvantages of each model and the extent to which each model reproduces human ARDS. …
Variable tidal volume ventilation improves lung mechanics and gas exchange in a rodent model of acute lung injury
SP Arold, R Mora, KR Lutchen… - … journal of respiratory …, 2002 - atsjournals.org
… ) to improve lung mechanics and oxygenation in the setting of acute lung injury depends on
… test this hypothesis we compared lung mechanics as well as blood oxygenation in a rodent …
… test this hypothesis we compared lung mechanics as well as blood oxygenation in a rodent …
Lung and brainstem cytokine levels are associated with breathing pattern changes in a rodent model of acute lung injury
… We conclude that breathing pattern changes in acute lung injury were associated with
increased levels of IL-1β in brainstem areas which integrate cardio-respiratory sensory input. …
increased levels of IL-1β in brainstem areas which integrate cardio-respiratory sensory input. …
Human models of acute lung injury
AG Proudfoot, DF McAuley… - Disease models & …, 2011 - journals.biologists.com
… In this article, we consider the clinical features of ALI, discuss the limitations of current
animal models and highlight how emerging human models of ALI might help to answer …
animal models and highlight how emerging human models of ALI might help to answer …
Using a non-invasive assessment of lung injury in a murine model of acute lung injury
S Lax, MR Wilson, M Takata… - BMJ Open Respiratory …, 2014 - bmjopenrespres.bmj.com
… multiple quantitative markers of lung injury and inflammation alongside non-invasive
monitoring of cardiopulmonary parameters during a mouse model of ALI. Our data revealed that …
monitoring of cardiopulmonary parameters during a mouse model of ALI. Our data revealed that …
Role of TNF-α in lung tight junction alteration in mouse model of acute lung inflammation
E Mazzon, S Cuzzocrea - Respiratory research, 2007 - Springer
… functional alterations in pulmonary TJ function in vivo as a result of acute lung inflammation
induced by carrageenan in mice. Herein, we demonstrate that acute lung injury is associated …
induced by carrageenan in mice. Herein, we demonstrate that acute lung injury is associated …
Endothelial cell-specific anticoagulation reduces inflammation in a mouse model of acute lung injury
J Lou, Y Hu, M Wu, L Che, Y Wu, Y Zhao… - Acta Pharmacologica …, 2019 - nature.com
… lung inflammation and the pathogenesis of acute lung injury (ALI). In this study, we explored
the roles of targeted endothelial anticoagulation in ALI using two strains of transgenic mice …
the roles of targeted endothelial anticoagulation in ALI using two strains of transgenic mice …
… inflammation in rats following exposure to combustion products of carbon–graphite/epoxy composite material: comparison to a rodent model of acute lung injury
GS Whitehead, KA Grasman, EC Kimmel - Toxicology, 2003 - Elsevier
… Pulmonary function and inflammation in the lungs of rodents … to that of a rodent model of
acute lung injury (ALI) produced … mechanisms of a model of lung vascular injury. We examined …
acute lung injury (ALI) produced … mechanisms of a model of lung vascular injury. We examined …
Anti-inflammatory and anti-fibrotic treatment in a rodent model of acute lung injury induced by sulfur dioxide
E Wigenstam, L Elfsmark, L Ågren, C Akfur… - Clinical …, 2018 - Taylor & Francis
… In this study, we employed a rat model of SO 2 -induced lung injury suitable for studying …
pulmonary fibrosis. An animal ventilator and a forced oscillation method were used to evaluate …
pulmonary fibrosis. An animal ventilator and a forced oscillation method were used to evaluate …
Mouse models of acute respiratory distress syndrome: a review of analytical approaches, pathologic features, and common measurements
F Aeffner, B Bolon, IC Davis - Toxicologic pathology, 2015 - journals.sagepub.com
… Lung injury scoring system adapted for mouse models of ARDS. … for common lesion scores
observed in mouse models of acute respiratory distress syndrome (ARDS). (A) Normal lung (…
observed in mouse models of acute respiratory distress syndrome (ARDS). (A) Normal lung (…
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