… of IFN expression and cellular responses to IFNs. In this review, we describe the innate
sensing … of SARS-CoV-2 and the mechanisms used by SARS-CoV-2 to evade type I and III IFN …

… role of immune response to SARS-CoV-2 infection as well as recent publications on
characteristics and outcomes of COVID-19, and their relationship with interferons type I and type III. …

… of the complex interplay between SARS-CoV-2 infection and the IFN system, highlighting
some … conserved IFN evasion strategies that are likely shared with SARS-CoV and MERS-CoV, …

… We tested the effect of type I IFN against SARS–CoV-2 compared with the SARS–CoV-1
from 2003. Two different cell lines were employed, namely the human bronchial epithelial Calu-…

… SARS-CoV-2 proteins that antagonize type I interferon (IFN-I) response. We found three
proteins that antagonize IFN… kinase 1 (TBK1) to suppress interferon regulatory factor 3 (IRF3) …

… pathogen of COVID-19, SARS-CoV-2, and host innate … SARS-CoV-2 induces overt but
delayed type-I interferon (IFN) responses. By screening 23 viral proteins, we find that SARS-CoV-…

… in IFN responses … IFN production as well as the importance of IFN timing and location for
disease outcome. We will further discuss the mechanisms that SARS-CoV-2 uses to evade IFN …

… IFNs and SARS-CoV-2. Human cells infected with SARS-CoV-2 in vitro produce low levels
of type I IFNs, and SARS-CoV-2 proteins can inhibit various steps in type I IFN production and …

… SARS-CoV-2 to recombinant human interferons α and β (IFNα/β). Treatment with IFN-α or
IFN-… The EC 50 of IFN-α and IFN-β treatment is 1.35 IU/ml and 0.76 IU/ml, respectively, in Vero …

… SARS-CoV-2 and … of IFN-I stimulation by SARS-CoV-2 alone but detect the failure to
counteract STAT1 phosphorylation upon IFN-I pretreatment, resulting in near ablation of SARS-CoV-…