The roles of perineuronal nets and the perinodal extracellular matrix in neuronal function

JW Fawcett, T Oohashi, T Pizzorusso - Nature Reviews Neuroscience, 2019 - nature.com
Perineuronal nets (PNNs) are extracellular matrix (ECM) chondroitin sulfate proteoglycan (CSPG)-containing
structures that surround the soma and dendrites of various mammalian …

Casting a wide net: role of perineuronal nets in neural plasticity

BA Sorg, S Berretta, JM Blacktop… - Journal of …, 2016 - Soc Neuroscience
Perineuronal nets (PNNs) are unique extracellular matrix structures that wrap around
certain neurons in the CNS during development and control plasticity in the adult CNS. They …

Diverse functions of perineuronal nets

M Karetko, J Skangiel-Kramska - Acta neurobiologiae experimentalis, 2009 - ane.pl
role of perineuronal nets is not fully elucidated yet. Perineuronal nets may play a beneficial
role … On the other hand, perineuronal nets create a barrier which limits neuronal plasticity and …

Perineuronal nets and their role in synaptic homeostasis

M Bosiacki, M Gąssowska-Dobrowolska… - International journal of …, 2019 - mdpi.com
… neurons and glial cells form perineuronal nets (PNNs) and … We also characterize the role
of ECM in the functioning of the … clinical aspects of perineuronal net impairment. Furthermore, …

Perineuronal nets: subtle structures with large implications

H Carceller, Y Gramuntell, P Klimczak… - The …, 2023 - journals.sagepub.com
Perineuronal nets (PNNs) are specialized structures of the extracellular matrix that surround
the soma and proximal dendrites of certain neurons in the central nervous system, …

Perineuronal nets: past and present

MR Celio, R Spreafico, S De Biasi… - Trends in …, 1998 - cell.com
… peripheral reticulum, or perineuronal net, is now recognized … as in the case of the perineuronal
net. This review traces the … anticipated current thinking on the role of perineuronal nets. …

An extracellular perspective on CNS maturation: perineuronal nets and the control of plasticity

D Carulli, J Verhaagen - International Journal of Molecular Sciences, 2021 - mdpi.com
… One mechanism that stands out is the formation of perineuronal nets (PNNs). In this review,
we address the role of PNNs in restricting critical period plasticity. Next, we discuss the …

[PDF][PDF] Perineuronal nets in neurodegeneration

S Lemarchant, S Wojciechowski, J Koistinaho - Oncotarget, 2016 - researchgate.net
… were enwrapped by a net, but it was only recently that neuroscientists started to intensely
investigate the role of this mysterious reticular structure. Today, perineuronal nets (PNNs) are …

Perineuronal nets and schizophrenia: the importance of neuronal coatings

BKY Bitanihirwe, TUW Woo - Neuroscience & Biobehavioral Reviews, 2014 - Elsevier
… Interestingly, these events coincide with the appearance of perineuronal nets (PNNs),
reticular structures composed of components of the extracellular matrix that coat a variety of cells …

The perineuronal net and the control of CNS plasticity

D Wang, J Fawcett - Cell and tissue research, 2012 - Springer
Perineuronal nets (PNNs) are reticular structures that surround the cell body of many … ,
before focusing our discussion on their unique roles in neuronal development and plasticity. The …