… Given that the PI3K/AKT pathway has manifested its … the roles of hyperactivation of
PI3K/AKT pathway in various human cancers. We state the abnormalities of PI3K/AKT pathway in …

… In this review, we will highlight the emerging role of the PI3K/Akt pathway in drug resistance
by discussing recent findings of a multi-level deregulation. Combinational and personalized …

… we discuss PI3K/Akt pathway components and … role for PI3K/Akt pathway in stimulation of
proliferation and survival in overexpressing ErbB2 cells. Further examples of PI3K/Akt pathway …

… of chemotherapy and inhibits PI3K/Akt and Wnt signalling, thus playing a key role in the cell
… GSK-3 with PI3K/Akt pathway is represented in Figure 1. The activation of Akt is also related …

… Silibinin prevents PI3K/AKT pathway inhibition by decreasing IRS1 phosphorylation on Tyr
[… ), whose overexpression can inactivate the whole PI3K pathway [25]. Since this protein was …

… Activation of PI3K/Akt PI3K–Akt pathway seems to be very significant component for … -3-OH
kinase (PI3K)–Akt (Akt; protein kinase identified in the AKT virus [also known as protein …

… PI3K/AKT pathway has important roles in the carcinogenesis since it has central impact
in the regulation of metabolic pathways, cell proliferation and survival, gene expression and …

… /mTOR are identified as having a key role in the pathogenesis of various … PI3K/AKT/mTOR
signal pathway is an important intracellular signal transduction pathway with a significant role …

… that activate this pathway in … roles for the PI3K-AKT pathway in both melanoma initiation
and therapeutic resistance. The availability of many inhibitors against the PI3K-AKT pathway is …

… The central role of AKT in the PI3Ks pathway makes it one of the most activated downstream
… It appears that the insensitivity to AZD6244 therapy is due to PI3K/AKT pathway activation, …