The Role of Renin–Angiotensin System in Diabetic Cardiomyopathy: A Narrative Review

JPT Batista, AOV Faria, TFS Ribeiro… - Life, 2023 - mdpi.com
diabetic cardiomyopathy. This review summarizes the studies that address the link between
cardiomyopathy … RAS plays an important role in the development and progression of diabetic

Cardiac-specific suppression of NF-κB signaling prevents diabetic cardiomyopathy via inhibition of the renin-angiotensin system

CM Thomas, QC Yong, RM Rosa… - American Journal …, 2014 - journals.physiology.org
… To investigate its role in diabetic cardiomyopathy, we used 3M mice in which NF-κB canonical
signaling is suppressed in the heart in response to multiple pathological stimuli (5, 20, 48). …

(Pro) renin receptor-mediated myocardial injury, apoptosis, and inflammatory response in rats with diabetic cardiomyopathy

X Dong, S Yu, Y Wang, M Yang, J Xiong, N Hei… - Journal of Biological …, 2019 - ASBMB
… Excessive activation of the renin-angiotensin system (RAS) in diabetic cardiomyopathy (… ,
and causes ventricular remodeling and heart failure in diabetes. (Pro)renin receptor (PRR) is a …

The cardiac (pro) renin receptor is primarily expressed in myocyte transverse tubules and is increased in experimental diabetic cardiomyopathy

KA Connelly, A Advani, S Kim, SL Advani… - Journal of …, 2011 - journals.lww.com
diabetic cardiomyopathy Given the importance of locally generated angiotensin II in the
pathogenesis of diabetic cardiomyopathy … -27 rat with streptozotocin-induced diabetes provides a …

The diabetic cardiomyopathy

R Tarquini, C Lazzeri, L Pala, CM Rotella, GF Gensini - Acta diabetologica, 2011 - Springer
… association between diabetes and cardiomyopathy, an … cellular alterations characterizing
diabetic cardiomyopathy (that … means of renin-angiotensin system activation, cardiac autonomic …

Intracellular renin protects cardiomyocytes from ischemic injury in diabetic heart

D Nonaka - Journal of Cardiovascular Diseases & …, 2015 - hama-med.repo.nii.ac.jp
renin expression increases during ischemia in diabetic hearts, and that increased renin protects
… Consistent with our results, overexpression of cardiac alternative renin transcript lacking …

Diabetic cardiomyopathy: an update of mechanisms contributing to this clinical entity

G Jia, MA Hill, JR Sowers - Circulation research, 2018 - Am Heart Assoc
… , renin–angiotensin–aldosterone system activation, cardiac … of cardiac metabolic abnormalities
have all been implicated in the development and progression of diabetic cardiomyopathy. …

Functional, structural and molecular aspects of diastolic heart failure in the diabetic (mRen-2) 27 rat

KA Connelly, DJ Kelly, Y Zhang, DL Prior… - Cardiovascular …, 2007 - academic.oup.com
… Given the over-expression of angiotensin II in human diabetic cardiomyopathy, we
hypothesized that combining hyperglycaemia with an enhanced tissue renin-angiotensin system …

Effects of (pro) renin receptor on diabetic cardiomyopathy pathological processes in rats via the PRR-AMPK-YAP pathway

J Xiong, X Dong, S Li, F Jiang, J Chen, S Yu… - Frontiers in …, 2021 - frontiersin.org
… The purpose of this study was to determine the role of PRR in the pathological progression
… of diabetic cardiomyopathy through YAP. We first established diabetic cardiomyopathy rats …

[HTML][HTML] Left ventricular hypertrophy in diabetic cardiomyopathy: a target for intervention

M Mohan, A Dihoum, IR Mordi, AM Choy… - Frontiers in …, 2021 - frontiersin.org
… Importantly regression of LVH with antihypertensive treatment especially renin angiotensin
system blockers reduces cardiovascular morbidity and mortality. However, this approach is …