… selectins or selectin ligands, long-term selectin blockade might not be a practical therapy
for chronic inflammatory diseases. However, it is possible that partial inhibition of selectin …

… of selectin modulators in the treatment of inflammatory diseases. … role of selectins in
the pathophysiology of inflammation, … selectins could be molecular targets for anti-inflammatory …

… (18, 19), and a critical role for platelet P-selectin in the recruitment of eosinophils and …
lung disease (20). Whether platelets alone may suffice to mediate inflammatory lung disease …

… -dependent selectin function reveals a complex role for selectins and their ligands during
inflammatory diseases. Among selectin ligands, mucin P-selectin glycoprotein ligand-1 (PSGL-…

… is deficient in mice null for PSGL-1, suggesting a role for PSGL-1 in solubilization Citation[139].
It may be that soluble E-selectin exacerbates symptoms in inflammatory disease through …

… inflammation, we further defined the role of selectins in driving an allergic late-phase response.
The absence of P- and E-selectin … of late-phase inflammation. These data suggest that L-…

… While our experiments were aimed at defining roles of membrane-associated P-selectin,
we also examined the effect of P-selectin presented to the PMN in the fluid phaseto directly …

… lung diseases such as … disease (COPD) or idiopathic pulmonary fibrosis (IPF). This review
summarizes the current progress in understanding the role of selectins during inflammation in …

… Thus targeting of Pselectin remains a strong clinical candidate for … in inflammatory
diseases. This review will discuss the role of P-selectin and describe the function of P-selectin …

… in L-selectin playing an important role in the development of autoimmune and chronic
inflammatory diseases… However much remains to be defined concerning L-selectin function. For …