An engineering study on the enhanced control and operation of continuous manufacturing of pharmaceutical tablets via roller compaction

R Singh, M Ierapetritou, R Ramachandran - International journal of …, 2012 - Elsevier
… Quality by Design (QbD) based manufacturing of the next generation of pharmaceutical …
integrated continuous pharmaceutical tablet manufacturing process via roller compaction

A continuous manufacturing model for the production of granules by roller compaction

RSFC Dias - 2017 - repositorio.ul.pt
Continuous manufacturing is an encouraging and a sustaining innovation in pharmaceutical
manufacturing, … , flexibility and robustness to the manufacturing process. In this field, the …

Continuous Line Roller Compaction

O Korhonen - Continuous Manufacturing of Pharmaceuticals …, 2017 - books.google.com
Roller compaction works inherently continuously thus it is very promising unit operation in the
continuous manufacturing … Granulation is often required in the manufacturing of tablets and …

Process analytical technology for continuous manufacturing of solid-dosage forms

M Fonteyne, J Vercruysse, F De Leersnyder… - TrAC Trends in …, 2015 - Elsevier
… One fair comment is that continuous manufacturing … The first monitoring technique applied
on roller compaction is acoustic … The in-line monitoring of roller compaction was also studied …

[图书][B] Continuous manufacturing of pharmaceuticals

P Kleinebudde, J Khinast, J Rantanen - 2017 - books.google.com
… His main research interests are solid dosage forms and pharmaceutical processes like
roll compaction/dry granulation, extrusion, and coating. He has published more than 200 …

Achieving continuous manufacturing for final dosage formation: challenges and how to meet them. May 20–21, 2014 continuous manufacturing symposium

S Byrn, M Futran, H Thomas, E Jayjock… - Journal of …, 2015 - Wiley Online Library
… cylinders (referred to as rollers) in a device known as a roller compactor to produce a compacted
… approach to tablet manufacturing is direct compaction. In direct compaction, material is …

Model-based control system design and evaluation for continuous tablet manufacturing processes (via direct compaction, via roller compaction, via wet granulation)

R Singh - Computer Aided Chemical Engineering, 2018 - Elsevier
… The continuous manufacturing process via roller compaction (RC… The roller compaction route
also starts with feeders, comill, and … After blender, the blend goes to a roller compactor. The …

Optimization of residence time distribution in RCDG and an assessment of its applicability in continuous manufacturing

A Wilms, P Kleinebudde - Particuology, 2021 - Elsevier
… strategies for continuous manufacturing processes in pharmaceutical manufacturing. Dry …
In this study, a step-change method to determine residence time in roll compaction/dry …

Continuous manufacturing of tablets with PROMIS-line—Introduction and case studies from continuous feeding, blending and tableting

SP Simonaho, J Ketolainen, T Ervasti… - European Journal of …, 2016 - Elsevier
… -line is an excellent tool for studying the fundamentals of continuous manufacturing of tablets.
… Dry granulation (roller compaction) operates inherently continuously. Also wet granulation …

Continuous manufacturing in pharmaceutical process development and manufacturing

CL Burcham, AJ Florence… - Annual review of …, 2018 - annualreviews.org
manufacturing platforms, and improved product quality assurance. The transformation from
batch to continuous manufacturingRoller compaction is a continuous dry granulation process…