… , the vulnerability of the mitochondrial DNA to ROS-mediated damage appears to be a
mechanism to amplify ROS stress in cancer cells. The escalated ROS generation in cancer cells …

… cancer cell. In this review, we summarize mitochondrial function and ROS generation, and
also highlight ROS-… –mTOR and MAPK signaling in cancer. Therefore, a better understanding …

… The use of pharmacological agents to promote NOX-mediated ROS generation in cancer
cells as a means to kill these cells remains to be explored. The synthetic retinoid N-(4-…

… agent that increases ROS generation, or that decreases ROS … in ROS can be exploited to
selectively kill cancer cells using β-… Oncogenic transformation of ovarian epithelial cells with H-…

… therapeutic approaches for cancers, including chemotherapy, … cell death, therefore ROS
are also used to kill cancer cells. … In the existed cancer cells an increased ROS generation …

… human pancreatic cancer cells is initiated by the generation of ROS, … We next wanted to see
whether ROS generation is an … pretreatment not only blocks ROS generation but also offers …

… cells. We hypothesized that the introduction of additional reactive oxygen species (ROS) or
… activity may selectively enhance cancer cell killing by generating oxidative agents through …

… have reported that glutaminolysis inhibition was associated to the depletion of the intracellular
GSH content and subsequent ROS generation, particularly in HL-60 cells characterized …

… in triple-negative breast cancer cells is mediated by elevated ROS level, we examined …
in cells pretreated with ROS scavenger N-acetyl cysteine (NAC). MDA-MB-231 cells were …

… The major site of ROS generation inside the cells is the mitochondrial electron transport
chain where electrons can escape their route and react with oxygen (8). This biologic reduction …