… high ROS1 expression, we also observed ROS1 translocations with low ROS1 expression.
Considering that crizotinib inhibits ROS1 protein and not specifically ROS1 rearrangements, …

… We have also encountered 2 cases of RET-translocated lung cancer that showed a
prominent “solid signet-ring cell pattern” (A. Yoshida and T. Shibata, 2012, unpublished data). …

… Sequencing of the inverse PCR product revealed that this patient's tumor has undergone
a chromosomal translocation between chromosomes 6 and 20 that fused the 3′ region of …

… ROS1 fusions using a limited amount of mRNA even from formalin-fixed, paraffin-embedded
tumor … on the present and futuristic diagnostic scenario of ROS1 identification in lung cancer. …

… [6] In case of translocation between ROS1 and a partner gene, the FISH will show at least
one split and one merged signal. Conversely, in case of 5’ deletion at the 6q22 region the …

… (ALK) gene in non‐small cell lung cancer (NSCLC) has stimulated renewed interest in … in
ROS1 and RET were identified in patients with NSCLC. Like ALK, genetic alterations in ROS1 …

… probe covering the distal part of ROS1 and fluorescein isothiocyanate–labeled probes (green)
situated proximal to the ROS1 gene to evaluate ROS1 translocations. FFPE slides were …

… the ROS1 gene occur in 1–2 % of non-small cell lung cancers (NSCLCs). Crizotinib, a highly
effective inhibitor of ROS1 … with advanced ROS1-positive NSCLC. Consequently, focus on …

… of a ROS1 translocation within a sample, it provides no information about the translocation
partner… the presence of known ROS1 rearrangements and identify the translocation partner in …

… Moreover, the real prevalence of ROS1 translocations is probably higher than that reported
in literature, as our capacity to detect gene rearrangements is improving. In particular, with …