Chemopreventive effects of rosmarinic acid on rat colon carcinogenesis

RA Furtado, BR Oliveira, LR Silva… - … Journal of Cancer …, 2015 - journals.lww.com
… lead to colon cancer. Rat and human ACF show defects in DNA content, morphology, and
proliferation kinetics, and mutations have been detected in key genes involved in colon cancer

Biochemical and molecular mechanisms underlying the chemopreventive efficacy of rosmarinic acid in a rat colon cancer

K Venkatachalam, S Gunasekaran… - European Journal of …, 2016 - Elsevier
colon carcinogenesis in rats. The increased incidence of aberrant crypts in the DMH exposed
rats … ) decrease of weight gain and growth rate in carcinogen exposed rats (groups 3–6), it …

The effect of rosmarinic acid on 1, 2-dimethylhydrazine induced colon carcinogenesis

K Venkatachalam, S Gunasekaran… - Experimental and …, 2013 - Elsevier
… This study was carried out to investigate the chemopreventive potential of rosmarinic acid
(RA) against 1,2-dimethylhydrazine (DMH) induced rat colon carcinogenesis by evaluating the …

Modulatory efficacy of rosmarinic acid on premalignant lesions and antioxidant status in 1, 2-dimethylhydrazine induced rat colon carcinogenesis

V Karthikkumar, G Sivagami, R Vinothkumar… - Environmental …, 2012 - Elsevier
Rosmarinic acid (RA), one of the major components of polyphenol possesses attractive …
) induced rat colon carcinogenesis by evaluating the circulatory antioxidant status and colonic

Rosmarinic acid inhibits DMH-induced cell proliferation in experimental rats

V Karthikkumar, G Sivagami… - Journal of basic and …, 2015 - degruyter.com
… effects of rosmarinic acid (RA) in 1,2-dimethylhydrazine (DMH)-induced rat colon carcinogenesis.
… of DMH induces multiple tumors in the rat colon, which mimics human colon cancer. …

Protective effects of rosmarinic acid against azoxymethane‐induced colorectal cancer in rats

N Ilhan, I Bektas, S Susam… - Journal of Biochemical …, 2022 - Wiley Online Library
… )-induced rat colon carcinogenesis by evaluating … Rats were fed a modified pellet diet (15.8%
peanut oil was added to the standard diet) during the experimental period. Colon cancer

[PDF][PDF] Promising therapeutic role of Rosmarinus officinalis successive methanolic fraction against colorectal cancer

HH Ahmad, AH Hamza, AZ Hassan… - Int. J. Pharm. Pharm …, 2013 - academia.edu
… The chemopreventive effect of rosmarinic acid on colon carcinogenesis is evidenced by the
decreased incidence and distribution of tumors along the colon. This effect of rosmarinic acid

Therapeutic potential of rosmarinic acid: A comprehensive review

M Nadeem, M Imran, T Aslam Gondal, A Imran… - Applied Sciences, 2019 - mdpi.com
… RA application, at a concentration of 5 mg/kg bw during 30 weeks in 1,2-dimethyldrazin
stimulated colon carcinogenesis in the rat at 20 mg/kg bw and significantly stopped tumor …

Rosmarinic acid and related dietary supplements: Potential applications in the prevention and treatment of cancer

J Zhao, L Xu, D Jin, Y Xin, L Tian, T Wang, D Zhao… - Biomolecules, 2022 - mdpi.com
… These extracts inhibited proliferation in breast cancer and colon cancer cell lines via the
mitogen-activated protein kinase (MAPK)/ extracellular signal-regulated kinases 1 and 2 (ERK1/…

[HTML][HTML] Rosmarinic acid represses colitis-associated colon cancer: A pivotal involvement of the TLR4-mediated NF-κB-STAT3 axis

BR Jin, KS Chung, S Hwang, SN Hwang, KJ Rhee… - Neoplasia, 2021 - Elsevier
… on colon cancer induction and found that inflammatory microenvironments could advance
colon cancer via … Enhanced TLR4 activation was confirmed in colon cancer patients with long-…