Interference with GABA transmission in the rostral ventromedial medulla: disinhibition of off-cells as a central mechanism in nociceptive modulation

MM Heinricher, V Tortorici - Neuroscience, 1994 - Elsevier
… The aim of the present study was to elucidate the medullarymodulating neurons in the
rostra1 ventromedial medullapain modulating neurons in the rostra1 ventral medulla: reflex-…

… of spinal cord neurones during hypertension involves the spinal GABAergic system and a pain modulatory center located at the caudal ventrolateral medulla

M Morato, D Pinho, T Sousa, I Tavares… - Journal of …, 2006 - Wiley Online Library
medulla (VLM), an important inhibitory component of the supraspinal endogenous pain
The VLMlat was further shown to be the VLM area responsible for pain modulation (Tavares …

Gainfully employing descending controls in acute and chronic pain management

K White, M Targett, J Harris - The Veterinary Journal, 2018 - Elsevier
… targets for pain modulation in … medulla (RVM) and the locus coeruleus (LC) which are directly
influenced by the ascending spinobulbar projections and higher centres to modulate spinal …

Neuronal loss in the rostral ventromedial medulla in a rat model of neuropathic pain

ML Leong, M Gu, R Speltz-Paiz, EI Stahura… - Journal of …, 2011 - Soc Neuroscience
… The number of neurons in the facial nucleus, which is adjacent to the RVM but not involved
in pain modulation, was unchanged (ipsilateral sham: 6267 ± 219; ipsilateral SNL 6204 ± 422…

Compensatory activation of cannabinoid CB2 receptor inhibition of GABA release in the rostral ventromedial medulla in inflammatory pain

MH Li, KL Suchland, SL Ingram - Journal of Neuroscience, 2017 - Soc Neuroscience
… rostral ventromedial medulla (RVM) is a relay in the descending pain modulatory system and
an important site of endocannabinoid modulation of pain. … Implications for pain modulation

A role for neurokinin-1 receptor neurons in the rostral ventromedial medulla in the development of chronic postthoracotomy pain

SG Khasabov, JCF Wang, DA Simone, GR Strichartz - Pain, 2017 - journals.lww.com
… postoperative pain differ from those that maintain that pain (eg… the persistence of pain in
CPTP depends on modulation of … medulla (RVM) drives descending facilitation of pain. In the …

Circuitry underlying antiopioid actions of cholecystokinin within the rostral ventromedial medulla

MM Heinricher, S McGaraughty… - Journal of …, 2001 - journals.physiology.org
… Moreover the fact that CCK prevents opioid activation ofoff cells without affecting inhibition
of oncells has important implications for the organization of the pain modulating circuitry …

Differential modulation of neurons in the rostral ventromedial medulla by neurokinin-1 receptors

TS Brink, C Pacharinsak… - Journal of …, 2012 - journals.physiology.org
… Encoding of noxious stimulus intensity by putative pain modulating neurons in the rostral
ventromedial medulla and by simultaneously recorded nociceptive neurons in the spinal dorsal …

Cerebral cortex modulation of pain

Y Xie, F Huo, J Tang - Acta Pharmacologica Sinica, 2009 - nature.com
… This paper reviews recent studies on pain modulation by the aforementioned cerebral …
that the dorsal reticular nucleus and rostral ventral medulla play crucial roles in mediating ACC-…

Descending modulation of spinal nociceptive processing

GF Gebhart - Der Schmerz, 1993 - Springer
medulla also failed to significantly affect stimulation thresholds in the PAG. In C, the rostroventral
medulla … In conclusion, my interest in pain modulation began with a focus on inhibition …