… on the CAR and other non-CAR molecules aimed to enhance CAR T cell efficacy and safety…
We also highlight the development of different types of inducible CAR T cells that can be …

… to the tumor and inhibition of T cell activity by an inhibitory tumor … CAR T cells through
genetic engineering addresses these limitations and improves the antitumor efficacy of CAR T cell …

… both due to the delivery system and the engineering technology. Here, we will review the
vectors and engineering tools used for CAR T-cell production at the clinical and preclinical level…

… of T cells with chimeric antigen receptors (CAR-T cells) has … of the CAR-T cell approach,
including the design of the CAR, … killer and other cell types, combining the CAR approach with …

… type of MHC that is presented by the APC (class I MHC or class II MHC), which subsequently
defines whether the T cell will differentiate into one of the two major T cell subsets, CD8+ (…

… -gate CAR-T cells. This research has laid the foundations for a whole new generation of
therapeutic CAR-T cells. Here, we review the most promising CAR-T cell safety strategies and …

… of CAR T cells in clinical studies, investigators are innovatively engineering CAR T cells in a
… These strategies aim to improve the safety and efficacy of CAR T cell therapies, broaden the …

… Here, we chose to engineer T cells with a NILV-S/MAR-based vector encoding a 2 nd … -engineered
CAR T cells are as efficient as LV-engineered CAR T cells to kill tumor cells both in …

… T cell activation, CAR gene transfer, T cell expansion, and Quality Control and Assurance
(QC/QA), upon which CAR T cells … affect the safety, efficacy, and scale of CAR T cell production…

… However, in clinical studies comparing 28z and 4-1bbz, their antitumor effect was almost
same, although bbz CAR T cells exhibited a more favorable safety profile than 28z [42,43]. …