… modafinil were safe and effective. In this paper we report on the long-term efficacy and safety
of modafinil … randomized double-blind period of either continuation of modafinil or placebo. …

… during 9 weeks of daily treatment with modafinil at therapeutic levels. The present analysis
assesses the long-term efficacy and safety of daily modafinil for the treatment of EDS in …

… Modafinil, an established treatment for narcolepsy, was … and safety in Japanese patients
with IH without long sleep time. … of modafinil versus placebo for IH without long sleep time. The …

… .19,20 Furthermore, modafinil carries lower potential for abuse … to aggregate safety results
across studies in disorders of sleep … context of the safety and tolerability of modafinil in patients …

… sleep-deprived individuals, modafinil improves mood, fatigue, sleepiness and cognition to a
similar extent as caffeine but has a longer duration … However, its effects on safety on the job …

… an influence on sleep homeostasis. Under normal conditions, the homeostatic drive of sleep
is enhanced … in the intensity and duration of sleep. This neurobiological feature is known as “…

… the main cause in 18.6% of night time accidents, and 3.9% of … extent of sleep deprivation
and its effect on driving safety, or … the acute use of modafinil by sleepy drivers may reduce road-…

… the long-term effects and safety profile of modafinil in children … modafinil on overnight sleep
characteristics. However, trends towards reduction in REM sleep, prolongation of REM sleep …

… sleep is as good or more effective than modafinil or amphetamine given at approximately the
same time… it would not be safe to remain awake using modafinil alone for longer than 60–64 …

… Safety outcomes All patients who received at least one dose of modafinil were included
in the safety analysis. During the 2-week stimulant washout period, 42 of the 151 patients (28%) …