Efficacy and safety of aerosolized tobramycin in cystic fibrosis

VB Pai, MC Nahata - Pediatric pulmonology, 2001 - Wiley Online Library
… Aerosolized tobramycin has been extensively used in cystic fibrosis … Aerosolized tobramycin
doses ranging from 80 mg twice or three … Tobramycin, nebulized at 600 mg three times daily, …

[HTML][HTML] Safety, efficacy and convenience of tobramycin inhalation powder in cystic fibrosis patients: the EAGER trial

MW Konstan, PA Flume, M Kappler, R Chiron… - … of Cystic Fibrosis, 2011 - Elsevier
… In summary, the safety profile of TIP was comparable with the currently approved formulation
of tobramycin, TIS, with the exception of cough, dysphonia and dysgeusia. Patient-reported …

Long-term safety and efficacy of tobramycin in the management of cystic fibrosis

E Vázquez-Espinosa, RM Girón… - … and clinical risk …, 2015 - Taylor & Francis
tobramycin dry powder efficacy in cystic fibrosis) compared TIP with placebo. EAGER
Citation30 (Establish a new gold standard efficacy and safety with tobramycin in cystic fibrosis) …

Safety of aerosol tobramycin administration for 3 months to patients with cystic fibrosis

AL Smith, BW Ramsey, DL Hedges, B Hack… - Pediatric …, 1989 - Wiley Online Library
tobramycin administration, 22 patients with cystic fibrosis were monitored while receiving
inhaled tobramycin … the end of the 12th week of administration of tobramycin aerosol. Sputum F! …

Pharmacokinetics and safety of tobramycin after once-daily administration in patients with cystic fibrosis

RD Bates, MC Nahata, JW Jones, K McCoy, G Young… - Chest, 1997 - Elsevier
Tobramycin is commonly used to treat respiratory tract infections in … cystic fibrosis. We
designed a study to determine the pharmacokinetics and safety of once-daily dosing of tobramycin

Efficacy, Safety, and Local Pharmacokinetics of Highly Concentrated Nebulized Tobramycin in Patients with Cystic Fibrosis Colonized with Pseudomonas aeruginosa

G Lenoir, YG Antypkin, A Miano, P Moretti, M Zanda… - Pediatric Drugs, 2007 - Springer
… with cystic fibrosis (CF). This trial was designed to investigate the efficacy and safety of a
highly concentrated (300mg/4mL) tobramycin … a 4-week treatment with tobramycin or placebo …

[HTML][HTML] Safety of inhaled (Tobi®) and intravenous tobramycin in young children with cystic fibrosis

S Hennig, K McKay, S Vidmar, K O'Brien, S Stacey… - … of Cystic Fibrosis, 2014 - Elsevier
… The aim of this study was to assess the safety of tobramycin solution for inhalation (TOBI®-TSI)
administered twice daily for 2 months/course concurrently to intravenous (IV) tobramycin

[HTML][HTML] Efficacy and safety of intravenous meropenem and tobramycin versus ceftazidime and tobramycin in cystic fibrosis

P Latzin, M Fehling, A Bauernfeind, D Reinhardt… - … of Cystic fibrosis, 2008 - Elsevier
… that meropenem in combination with tobramycin is as useful for treatment of P. aeruginosa
infection in cystic fibrosis patients as ceftazidime with tobramycin. In addition to its clinical …

Long-term safety of tobramycin inhalation powder in patients with cystic fibrosis: phase IV (ETOILES) study

U Sommerwerck, I Virella-Lowell… - … medical research and …, 2016 - Taylor & Francis
… Long-term safety and efficacy of tobramycin inhalation powder in cystic fibrosis patients
with P. aeruginosa: the edit trial and its two open-label extension studies. 27th North American …

Novel tobramycin inhalation powder in cystic fibrosis subjects: pharmacokinetics and safety

DE Geller, MW Konstan, J Smith… - Pediatric …, 2007 - Wiley Online Library
safety of tobramycin inhalation powder (TIP), a novel dry-powder formulation designed to
deliver a high payload of tobramycin … 300 mg dose of tobramycin solution for inhalation (TSI) as …