Inflammatory role of high salt level in tumor microenvironment

S Amara, V Tiriveedhi - International journal of …, 2017 - spandidos-publications.com
… As tumors are known to have high salt microenvironment (28), our data strongly suggest that
high salt … accumulated in tumor microenvironment (29). The cytokine array expressed in the …

High salt inhibits tumor growth by enhancing anti-tumor immunity

R Willebrand, I Hamad, L Van Zeebroeck… - Frontiers in …, 2019 - frontiersin.org
… by many tumors. It is well-documented that the tumor microenvironment frequently induces
an … Important players in the tumor microenvironment are myeloid cells, which can support …

High salt diet may promote progression of breast tumor through eliciting immune response

J Chen, X Liu, H Huang, F Zhang, Y Lu, H Hu - International …, 2020 - Elsevier
… believed to regulate tumor progression by altering the tumor microenvironment. Of note, a
high salt diet is a risk factor for various diseases. However, the role of high salt intake in the …

High-salt diet inhibits tumour growth in mice via regulating myeloid-derived suppressor cell differentiation

W He, J Xu, R Mu, Q Li, D Lv, Z Huang, J Zhang… - Nature …, 2020 - nature.com
… that high-salt intake promotes inflammation in various tissue microenvironments, which may
… However, in the tumour microenvironment, stimulating the pro-inflammatory activities of …

Cancer and the tumor microenvironment: a review of an essential relationship

F Mbeunkui, DJ Johann - Cancer chemotherapy and pharmacology, 2009 - Springer
… Monitoring the change in the tumor microenvironment via molecular and cellular profiles
as tumor progresses would be vital for identifying cell or protein targets for cancer prevention …

Tumor microenvironment is multifaceted

C Sautès-Fridman, J Cherfils-Vicini, D Damotte… - Cancer and Metastasis …, 2011 - Springer
… immune response, we suggest that the microenvironment of early-stage NSCLC may …
tumor microenvironments are multifaceted and strongly influence tumor progression and anti-tumor

Metabolic codependencies in the tumor microenvironment

P Dey, AC Kimmelman, RA DePinho - Cancer Discovery, 2021 - AACR
… acting on cancer cells in the tumor microenvironment. Cancer cell–intrinsic mechanisms …
in the tumor microenvironment and how such mechanisms may be targeted therapeutically. …

High salt intake attenuates breast cancer metastasis to lung

Y Xu, W Wang, M Wang, X Liu, MH Lee… - Journal of agricultural …, 2018 - ACS Publications
salt intake might represent a dietary risk factor for cancer. For example, high salt was assumed
to be genotoxic as high salt … role in tumor microenvironment, while high salt intake was …

[HTML][HTML] High salt induces anti-inflammatory MΦ2-like phenotype in peripheral macrophages

S Amara, M Whalen, V Tiriveedhi - Biochemistry and biophysics reports, 2016 - Elsevier
… induces an anti-inflammatory MΦ2-like macrophage phenotype with poor phagocytic and
potentially reduced antigen presentation capacity commonly found in tumor microenvironment. …

[HTML][HTML] Ex vivo high salt activated tumor-primed CD4+ T lymphocytes exert a potent anti-cancer response

V Tiriveedhi, MT Ivy, EL Myles, R Zent, JC Rathmell… - Cancers, 2021 - mdpi.com
… cells with weak antigen specificity and poor anti-tumor effect [16,17]. Further, adverse
immunosuppressive tumor microenvironment limits the activation of these transferred TILs. Studies …