Angiotensin II receptor blockade administered after injury improves muscle regeneration and decreases fibrosis in normal skeletal muscle
HS Bedair, T Karthikeyan, A Quintero… - … American journal of …, 2008 - journals.sagepub.com
… In light of the possibility that our work may pave the way for clinical trials on the effect of
losartan as an antifibrotic therapy to promote optimal skeletal muscle healing, it is important to …
losartan as an antifibrotic therapy to promote optimal skeletal muscle healing, it is important to …
Chronic Respiratory Disease: COPD, IPF
RA Incalzi, FL Fimognari - Optimizing Pharmacotherapy in Older Patients …, 2023 - Springer
… or sarcopenic patients to benefit from topical therapy. Only in … patients aerosol therapy should
be considered a therapeutic … patients, the possibility to treat non-IPF-ILDs with antifibrotic …
be considered a therapeutic … patients, the possibility to treat non-IPF-ILDs with antifibrotic …
Myostatin and muscle atrophy during chronic kidney disease
S Bataille, P Chauveau, D Fouque… - Nephrology Dialysis …, 2021 - academic.oup.com
… sarcopenia, is associated with lower health-related quality of life, and greater disability and
mortality risk in chronic kidney disease (CKD) patients [1, … and a possible anti-fibrotic effect on …
mortality risk in chronic kidney disease (CKD) patients [1, … and a possible anti-fibrotic effect on …
Pharmacological Treatments and Therapeutic Targets in Muscle Dystrophies Generated by Alterations in Dystrophin-Associated Proteins
A Luna-Angulo, C Landa-Solís, RE Escobar-Cedillo… - Medicina, 2024 - mdpi.com
… patients treated with steroids showed 22.38% CT, compared to 30% observed in patients
without treatment… to the CT, as patients with steroid treatment showed a higher percentage of …
without treatment… to the CT, as patients with steroid treatment showed a higher percentage of …
Aberrant repair and fibrosis development in skeletal muscle
CJ Mann, E Perdiguero, Y Kharraz, S Aguilar… - Skeletal muscle, 2011 - Springer
… Sarcopenia seems to occur by mechanisms that partly are unique to it, and partly are … IL-2,
all of which have been found to be anti-fibrotic cytokines. By contrast, CD4+ Th2 cells promote …
all of which have been found to be anti-fibrotic cytokines. By contrast, CD4+ Th2 cells promote …
Muscle-targeted nanoparticles strengthen the effects of small-molecule inhibitors in ameliorating sarcopenia
J Wang, Y He, B Wang, R Yin, B Chen, H Wang - Nanomedicine, 2023 - Taylor & Francis
… Senescence-accelerated mouse P8 (SAMP8) mice were used in this study as a sarcopenia
animal model, with the onset at month 8 [17,18]. SAMP8 mice (male, 10 weeks old) were …
animal model, with the onset at month 8 [17,18]. SAMP8 mice (male, 10 weeks old) were …
Systemic Transfusion of Human Umbilical Cord-Derived Mesenchymal Stromal Cells―Toward Less Invasive and More Effective Cell Therapy for Severe Peripheral …
T Nagai - Circulation Journal, 2023 - jstage.jst.go.jp
… , which is associated with sarcopenia. In this regard, the … -10 secretion, causing an anti-fibrotic
effect, because most organs of … et al suggest the potential of therapeutic use of UC-MNSCs …
effect, because most organs of … et al suggest the potential of therapeutic use of UC-MNSCs …
[HTML][HTML] Diet and exercise reduce pre-existing NASH and fibrosis and have additional beneficial effects on the vasculature, adipose tissue and skeletal muscle via …
AM van den Hoek, JCBC De Jong, N Worms… - Metabolism, 2021 - Elsevier
… , IL1B and IFNG activities were among the top 10 URs deactivated by combination therapy
which is consistent with the observed anti-fibrotic effects of the combined lifestyle treatment. …
which is consistent with the observed anti-fibrotic effects of the combined lifestyle treatment. …
Changes in body weight reflect disease progression in pleuroparenchymal fibroelastosis
Y Kinoshita, T Utsunomiya, Y Koide, K Wada… - … Medicine and Research, 2023 - Elsevier
… and is a treatment option for patients with cancer… patients was reported to be 23%–58% [13],
[14], [15]. Currently, there is no established treatment for PPFE, and the efficacy of antifibrotic …
[14], [15]. Currently, there is no established treatment for PPFE, and the efficacy of antifibrotic …
MyMD-1 improves health span and prolongs life span in old mice: A noninferiority study to rapamycin
E Sabini, A O'Mahony, P Caturegli - The Journals of Gerontology …, 2023 - academic.oup.com
… Therapies endowed with both anti-inflammatory and antifibrotic actions, thus, represent a
compelling strategy to ameliorate age-related conditions. We recently reported that MyMD-1, a …
compelling strategy to ameliorate age-related conditions. We recently reported that MyMD-1, a …