Mechanisms of antiviral immune evasion of SARS-CoV-2

DK Beyer, A Forero - Journal of molecular biology, 2022 - Elsevier
… Additional inhibition of antiviral responses is due to deficits in RNA maturation. SARS-CoV-2 …
Blockade of nuclear export of IFN and ISG mRNA inhibits antiviral immunity. This can be …

[HTML][HTML] The modulation of mucosal antiviral immunity by immunobiotics: could they offer any benefit in the SARS-CoV-2 pandemic?

J Villena, H Kitazawa - Frontiers in Physiology, 2020 - frontiersin.org
… , which identified non-immune respiratory cells as crucially important for early antiviral immunity
and their interaction with immune cells important for late antiviral resistance (Bradley et al…

The role of SARS-CoV-2 nucleocapsid protein in antiviral immunity and vaccine development

H Yu, F Guan, H Miller, J Lei, C Liu - Emerging microbes & …, 2023 - Taylor & Francis
… The SARS-CoV-2 nucleocapsid protein is a structural protein … of COVID-19 and antiviral
immunity against SARS-CoV-2. Here, … , antiviral innate immunity, and antiviral adaptive immunity. …

[HTML][HTML] RIG-I-induced innate antiviral immunity protects mice from lethal SARS-CoV-2 infection

S Marx, BM Kümmerer, C Grützner, H Kato… - … Therapy-Nucleic Acids, 2022 - cell.com
SARS-CoV-2, like other betacoronaviruses, possesses multiple features that allow it to
subvert our antiviral defenses and cause disease. SARS-CoV-2 codes for several structural and …

Suppression of MDA5-mediated antiviral immune responses by NSP8 of SARS-CoV-2

Z Yang, X Zhang, F Wang, P Wang, E Kuang, X Li - BioRxiv, 2020 - biorxiv.org
… type I interferon and antiviral agents indicates that SARS-CoV-2 escapes from antiviral
immune responses via an unknown mechanism. Here, we report that SARS-CoV-2 nonstructural …

[HTML][HTML] Impairment of antiviral immune response and disruption of cellular functions by SARS-CoV-2 ORF7a and ORF7b

T García-García, R Fernández-Rodríguez, N Redondo… - IScience, 2022 - cell.com
SARS-CoV-2, the causative agent of the present COVID-19 pandemic, possesses eleven
accessory proteins encoded in its genome, and some have been implicated in facilitating …

[HTML][HTML] Sex differences in antiviral immunity in SARSCoV‐2 infection: mitochondria and mitomiR come into view

E Iessi, C Cittadini, S Anticoli, K Fecchi… - Acta Physiologica …, 2021 - ncbi.nlm.nih.gov
… to evade the interferon I-mediated host immune responses by targeting mitochondria and,
in … immunity evasion is that of SARS-CoV virus, closely related and homologous to SARS-CoV-…

[HTML][HTML] SARS-CoV-2 spike antagonizes innate antiviral immunity by targeting interferon regulatory factor 3

RS Freitas, TF Crum, K Parvatiyar - Frontiers in Cellular and Infection …, 2022 - frontiersin.org
… Further biochemical experiments uncovered SARS-CoV-2 … by which SARS-CoV-2 evades
the host innate antiviral immune … to how SARS-CoV-2 may subvert innate antiviral immunity to …

[HTML][HTML] SARS-CoV-2 mRNA vaccines decouple anti-viral immunity from humoral autoimmunity

JR Jaycox, C Lucas, I Yildirim, Y Dai, EY Wang… - Nature …, 2023 - nature.com
… vaccines decouple SARS-CoV-2 immunity from autoantibody … the SARS-CoV-2 S1 receptor
binding domain (SARS-CoV-2-… coronavirus spike RBD proteins, including SARS-CoV-2 RBD …

[HTML][HTML] Targeting liquid–liquid phase separation of SARS-CoV-2 nucleocapsid protein promotes innate antiviral immunity by elevating MAVS activity

S Wang, T Dai, Z Qin, T Pan, F Chu, L Lou, L Zhang… - Nature Cell …, 2021 - nature.com
… To further elucidate the role of SARS2-NP in the regulation of innate antiviral immunity in
mice, we … and observe the effects of NPs on virulence and antiviral immunity (Fig. 3a). All three …