… virus remains unknown. Here we show that the replication of Omicron is substantially attenuated
in … -type SARS-CoV-2 (HKU-001a) and previous variants, which may explain its reduced …

… influence of ORF8 on replication in the context of a full replicating SARS-CoV genome, based
… We find that the 29 nt deletion conferred an attenuation of replication level irrespective of …

… These data support development of VSV-SARS-CoV-2 as an attenuated, replication-…
SARS-CoV-2. Because of this data, we hypothesized that a replicating VSV-eGFP-SARS-CoV-2 …

… attenuated SARS-CoV-2 (with deleted accessory proteins and rewired TRS) that can potentially
serve as a live-attenuated … ∆3a in viral attenuation, we compared the replication kinetics …

… Based on the arguments presented in Section 3, FCS deletion appears to be the best
strategy for achieving an attenuated but replicating SARS-CoV-2 vaccine. This finding is …

… Our finding that BA.1 is strongly attenuated in iPSC-derived … and cardiomyopathies compared
to other SARS-CoV-2 VOCs. … of attenuated forms of BA.5 and future SARS-CoV-2 variants. …

… a vectored SARS-CoV-2 vaccine candidate for intranasal immunization of infants and young
children. The vaccine is based on an attenuated, replication-competent parainfluenza virus …

… critical attenuating mutations, which dampen viral RNA replication and … SARS-CoV-2
replication and reveals deficits in nonstructural protein function underlying Omicron attenuation…

… SARS-COV-2 has recently emerged as a new public health threat. Herein, we report that
the FDA-approved drug, auranofin, inhibits SARS-COV-2 replication … expression of SARS-COV-…

… for wild type and attenuated respiratory viruses in the … live attenuated respiratory virus
vaccine replication and pathogenicity in the human lung prior to phase one trials. Live attenuated …