… in proS processing at the S1/S2 and S2′ sites, we next evaluated the activity of three
novel nontoxic, cell-permeative furin-like inhibitors developed by Boston Pharmaceuticals and …

… -2 spike protein or any candidate drug that could block Furin activity and impede further
biophysical processes. Furthermore, the allele frequency was also high, suggesting its presence …

… the SARS-CoV-2 S protein is cleaved by endogenous furin in … with pCAGGS plasmid encoding
the SARS-CoV-2 S protein with … antiviral activity of a combination of T-ex5 PPMO and furin …

… mutant than against parental SARS-CoV-2, probably … furin cleavage site in infection with
SARS-CoV-2 and highlight the importance of this site for evaluating the neutralization activities …

… furin in the entry SARS-CoV-2 into host cells. Furthermore, we evaluate available peptide and
non-peptide furin … This hypothesis implies that the activity of furin is paramount to the virus …

… to SARS-CoV, a better understanding of the role of the furin cleavage site during SARS-CoV…
system to generate a SARS-CoV-2 mutant that lacked the furin cleavage site insertion 14 . …

… SARS-coronavirus 2 (SARS-CoV-2) infection. This study focuses on host proteases that
proteolytically activate the SARS-CoV… at a putative furin substrate motif at SARS-CoV-2 spikes by …

… activity of cell–cell fusion [Citation8]. Our results indicate that overexpression of furin can also
increase SARS-CoV … cells, although not as much as in SARS-CoV-2 (about fivefold, Figure …

… The protease responsible for this activity is thought to be furin but this conclusion is largely
based on experiments using small molecule inhibitors [3,26,36]. Here we show that genetic …

… (honokiol and magnolol) on furin-like enzymatic activity using a fluorogenic substrate with
… inhibited furin-like enzymatic activity. We further examined the anti-SARS-CoV-2 activity of …