… A prime target of drug-discovery efforts is the SARS-CoV-2 main protease (M pro ). The
main proteases of different coronaviruses, including SARS-CoV-2, SARS-CoV and Middle East …

… the main proteases of SARS-CoV-2, SARS-CoV and MERS-CoV … of SARS-CoV-2 M pro
inhibitors that were based on previous … targeting the SARS-CoV or MERS-CoV main proteases. …

… Structure of the SARS coronavirus main proteinase as an active C2 crystallographic dimer.
Acta Crystallogr Sect F Struct Biol Cryst Commun 61, 964-966. Xue, X., Yang, H., Shen, W., …

… of the hydrated SARS-CoV-2 main protease by means of 2.0 μs … peptide substrate, the
monomeric protease exhibits a stable … crystallographic studies on the SARS-CoV-2 enzyme and, …

… severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease M pro (also …
SARS-CoV-2 3CL pro inhibitors. To better understand the characteristics of SARS-CoV-2 …

… the main protease of SARS-CoV-2 (IC 50 = 2.39 ± 0.63 μM) as well as the 3C proteases (3C …
against betacoronaviruses of clade b (SARS-CoV-2 and SARS-CoV), we sacrificed the goal …

… are four other HCV protease inhibitors which … main protease of SARS-CoV-2. Telaprevir,
also a covalent inhibitor of serine protease 33 , loses inhibition activity against M pro of SARS-…

… by a newly discovered coronavirus. A key … is the main protease 3CL pro (also termed
SARS-CoV 3CL pro ). We have cloned and expressed in Escherichia coli the full-length SARS-CoV …

… targeting SARS-CoV-2 M pro designed by Pfizer are under clinical trials, no SARS-CoV-2 …
Here, we collect a comprehensive list of 817 available SARS-CoV-2 and SARS-CoV M pro …

… in its monomeric form, since it inactivates the protease by disrupting the M pro dimer. …
SARS-CoV-2 lineages. We analyzed the most widespread amino acid substitutions in SARS-CoV-2 …