Probing the biophysical constraints of SARS-CoV-2 spike N-terminal domain using deep mutational scanning
… scanning, which combines saturation mutagenesis and next-generation sequencing (30).
Previous studies have applied deep mutational scanning … Although deep mutational scanning …
Previous studies have applied deep mutational scanning … Although deep mutational scanning …
Stabilization of the SARS-CoV-2 receptor binding domain by protein core redesign and deep mutational scanning
AC Leonard, JJ Weinstein, PJ Steiner… - … design and selection, 2022 - academic.oup.com
… Illumina sequencing, the mutagenic library was divided into 2 … prepared by separate nicking
mutagenesis reactions. Library … To screen the core residue mutagenic library for protease-…
mutagenesis reactions. Library … To screen the core residue mutagenic library for protease-…
[HTML][HTML] Deep mutational scanning of SARS-CoV-2 receptor binding domain reveals constraints on folding and ACE2 binding
… The entry receptor for both SARS-CoV-2 and the original SARS-CoV (which we refer to
here as SARS-CoV-1) is the human cell-surface protein angiotensin converting enzyme 2 (ACE2)…
here as SARS-CoV-1) is the human cell-surface protein angiotensin converting enzyme 2 (ACE2)…
Deep mutagenesis scanning using whole trimeric SARS-CoV-2 spike highlights the importance of NTD-RBD interactions in determining spike phenotype
R Kugathasan, K Sukhova, M Moshe, P Kellam… - PLoS …, 2023 - journals.plos.org
… This study uses deep mutagenesis scanning with whole trimeric spike displayed on
mammalian cells to screen for mutations that increase ACE2 binding and escape antibodies. We …
mammalian cells to screen for mutations that increase ACE2 binding and escape antibodies. We …
[HTML][HTML] Serine-scanning mutagenesis studies of the C-terminal heptad repeats in the SARS coronavirus S glycoprotein highlight the important role of the short helical …
KE Follis, J York, JH Nunberg - Virology, 2005 - Elsevier
… The fusion subunit of the SARS-CoV S glycoprotein contains two regions of hydrophobic …
serine-scanning mutagenesis to the C-terminal-most heptad-repeat region in the SARS-CoV S …
serine-scanning mutagenesis to the C-terminal-most heptad-repeat region in the SARS-CoV S …
Deep mutagenesis in the study of COVID-19: a technical overview for the proteomics community
E Procko - Expert review of proteomics, 2020 - Taylor & Francis
… Deep mutagenesis or deep mutational scanning take advantage of next-generation …
prominent studies of SARS coronavirus 2 (SARS-CoV-2) have used deep mutagenesis to address …
prominent studies of SARS coronavirus 2 (SARS-CoV-2) have used deep mutagenesis to address …
[HTML][HTML] Deep mutational scanning identifies SARS-CoV-2 Nucleocapsid escape mutations of currently available rapid antigen tests
… in continuously emerging variants of SARS-CoV-2 are a … platform and deep mutational
scanning. The results provide a … any possible future variants of SARS-CoV-2, establishing the …
scanning. The results provide a … any possible future variants of SARS-CoV-2, establishing the …
In silico mutagenesis-based remodelling of SARS-CoV-1 peptide (ATLQAIAS) to inhibit SARS-CoV-2: structural-dynamics and free energy calculations
A Khan, S Umbreen, A Hameed, R Fatima… - Interdisciplinary …, 2021 - Springer
… mutagenesis-based remodeling of SARs-CoV-1 peptide (ATLQAIAS) was performed to inhibit
the activities of 3CLpro of SARS-CoV… this alanine scanning mutagenesis and residue scan …
the activities of 3CLpro of SARS-CoV… this alanine scanning mutagenesis and residue scan …
Functional and antigenic characterization of SARS-CoV-2 spike fusion peptide by deep mutational scanning
… Furthermore, mutagenesis described in this study was performed in the S2 region instead
of the immunodominant RBD in the S1 subunit. As a result, most people should have robust …
of the immunodominant RBD in the S1 subunit. As a result, most people should have robust …
Comprehensive deep mutational scanning reveals the immune-escaping hotspots of SARS-CoV-2 receptor-binding domain targeting neutralizing antibodies
… We performed combinatorial scanning mutagenesis in protein complexes, depending on the
selected mutation sites. For each single mutant, the differences in the free energy of binding …
selected mutation sites. For each single mutant, the differences in the free energy of binding …
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