Gene of the month: the 2019-nCoV/SARS-CoV-2 novel coronavirus spike protein

TS Pillay - Journal of clinical pathology, 2020 - jcp.bmj.com
… In conclusion, the spike protein of SARS-CoV-2 plays a critical and fundamental role in viral
infection and in comparison with SARS-CoV the structure has evolved to exploit respiratory …

Silencing of SARS-CoV spike gene by small interfering RNA in HEK 293T cells

Z Qin, P Zhao, X Zhang, J Yu, M Cao, L Zhao… - Biochemical and …, 2004 - Elsevier
… of SARS-CoV spike gene, we performed real-time quantitative PCR using primers specific
to spike gene … , the relative expression of SARS-CoV spike gene in each RNA transcript was …

[HTML][HTML] The spike gene is a major determinant for the SARS-CoV-2 Omicron-BA. 1 phenotype

GT Barut, NJ Halwe, A Taddeo, JN Kelly… - Nature …, 2022 - nature.com
… Importantly, we show that the spike gene is a major determinant in the Omicron-BA.1 …
SARS-CoV-2 clones differing only by the expression of the spike protein of the respective VOCs. …

[HTML][HTML] Silencing SARS-CoV Spike protein expression in cultured cells by RNA interference

Y Zhang, T Li, L Fu, C Yu, Y Li, X Xu, Y Wang, H Ning… - FEBS letters, 2004 - Elsevier
… we targeted the Spike protein of SARS-CoV using … coronavirus Spike protein plays a critical
role in virus infection. Therefore, we chose the S gene as a target for inhibition of SARS-CoV

Characterization of humoral responses in mice immunized with plasmid DNAs encoding SARS-CoV spike gene fragments

F Zeng, KYC Chow, CC Hon, KM Law, CW Yip… - Biochemical and …, 2004 - Elsevier
… In the present study, different truncated fragments of SARS-CoV S gene were cloned into
two mammalian expression vectors, with or without secreting signal sequence, and used to …

[HTML][HTML] A selective sweep in the Spike gene has driven SARS-CoV-2 human adaptation

L Kang, G He, AK Sharp, X Wang, AM Brown… - Cell, 2021 - cell.com
… that leverages information from more than 182,000 SARS-CoV-2 genomes, we … in Spike
and several other regions, has likely played a critical role in the adaptive evolution of SARS-CoV-…

[HTML][HTML] SARS-CoV-2 Delta (B. 1.617. 2) variant: a unique T478K mutation in receptor binding motif (RBM) of spike gene

H Jhun, HY Park, Y Hisham, CS Song, S Kim - Immune network, 2021 - ncbi.nlm.nih.gov
… Mainly, there are 4 types of current COVID-19 vaccines; whole SARS-CoV-2 virus, mRNA, …
the genetic information of spike (S) gene on the envelop of SARS-CoV-2 except SARS-CoV-2 …

[HTML][HTML] The genetic sequence, origin, and diagnosis of SARS-CoV-2

H Wang, X Li, T Li, S Zhang, L Wang, X Wu… - European Journal of …, 2020 - Springer
… of the reagent to different gene regions is indeed different [41]… loci of two or three target genes.
Furthermore, reagent reaction … SARS-CoV-2 internal nucleoprotein (NP) and surface spike

[HTML][HTML] Tracking SARS-CoV-2 Omicron diverse spike gene mutations identifies multiple inter-variant recombination events

J Ou, W Lan, X Wu, T Zhao, B Duan, P Yang… - … and Targeted Therapy, 2022 - nature.com
… A multitude of mutations (more than 30) in the spike gene (S) of … Mutations in the SARS-CoV-2
spike gene have altered … AY.x) variants with spike gene mutations confirmed these effects …

[HTML][HTML] Pango lineage designation and assignment using SARS-CoV-2 spike gene nucleotide sequences

Á O'Toole, OG Pybus, ME Abram, EJ Kelly, A Rambaut - BMC genomics, 2022 - Springer
… the spike gene of SARS-CoV-2. It is therefore important to understand how much information
about Pango lineage status is contained in spike-… and assigned to spike-only nucleotide …